Profile and value of FIB-4 in patients with dual chronic hepatitis C and B

Journal of Gastroenterology and Hepatology
Chun-Jen LiuT-C Tseng

Abstract

Patients with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection are at risk of developing adverse outcomes. Coinfection with both viruses may further increase the risk. Currently, little is known about the role of fibrosis-4 (FIB-4) index, a simple liver fibrosis stage biomarker, in predicting the clinical outcomes. We retrospectively enrolled 152 non-cirrhotic patients with dual chronic HCV and HBV infection: 56 patients received pegylated interferon/ribavirin therapy, while 96 patients remained untreated. The association between the FIB-4 index and the incidence of liver cirrhosis and hepatocellular carcinoma (HCC) was explored. After a 9.88-year follow-up, the incidence of hepatitis B surface antigen seroclearance was 4.97 (95% confidence interval: 3.13-7.89) per 100 person-years in the treated group and was 1.77 (1.10-2.85) in the untreated group. Of the treated group, only three and six patients developed HCC and liver cirrhosis, respectively, while 17 and 23 patients developed HCC and liver cirrhosis, respectively, in untreated group. Baseline FIB-4 index correlated with the development of liver cirrhosis in multivariable analysis of all subjects. High baseline FIB-4 index (per 1 point increase) in the ...Continue Reading

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Citations

Dec 17, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adeel A ButtObaid S Shaikh
Apr 4, 2020·Journal of Viral Hepatitis·Chih-Wei TsengKuo-Chih Tseng
Jul 16, 2020·Viruses·Yi-Fen Shih, Chun-Jen Liu
Jul 31, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Xiao-Lan XuBing Ruan

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