Profile of abemaciclib and its potential in the treatment of breast cancer

OncoTargets and Therapy
James M Martin, Lori J Goldstein

Abstract

Hormone-receptor-positive breast cancer is the most common subtype of breast cancer among patients with both early-stage and metastatic disease. Recent advances in the understanding of its pathophysiology have led to the discovery and utilization of targeted inhibitors to cyclin-dependent kinases 4 and 6 (CDK4/6). There are currently three available CDK4/6 inhibitors available for use in USA: palbociclib, ribociclib, and abemaciclib. Their oral administration and tolerable toxicities make this class of agents appealing to both patients and health care providers. Abemaciclib, the most recently approved CDK4/6 inhibitor, has unique pharmacologic properties and potential toxicities. This review highlights the current understanding of abemaciclib and discusses its current and future roles in the treatment of breast cancer.

Citations

Dec 11, 2020·Medicinal Research Reviews·Denisa HendrychováVladimír Kryštof
Jul 27, 2021·Journal of Biochemical and Molecular Toxicology·Zeynep OzmanMehmet R Sekeroglu

❮ Previous
Next ❯

Methods Mentioned

BETA
xenografts
xenograft

Clinical Trials Mentioned

NCT02513394
NCT02947685
NCT02422615
NCT02278120
NCT02308020
NCT02675231
NCT03130439
NCT02441946
NCT03155997

Software Mentioned

monarcHER

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.