Profile of Arachidonic Acid-Derived Inflammatory Markers and Its Modulation by Nitro-Oleic Acid in an Inherited Model of Amyotrophic Lateral Sclerosis

Frontiers in Molecular Neuroscience
Andrés TrostchanskyHomero Rubbo

Abstract

The lack of current treatments for amyotrophic lateral sclerosis (ALS) highlights the need of a comprehensive understanding of the biological mechanisms of the disease. A consistent neuropathological feature of ALS is the extensive inflammation around motor neurons and axonal degeneration, evidenced by accumulation of reactive astrocytes and activated microglia. Final products of inflammatory processes may be detected as a screening tool to identify treatment response. Herein, we focus on (a) detection of arachidonic acid (AA) metabolization products by lipoxygenase (LOX) and prostaglandin endoperoxide H synthase in SOD1G93A mice and (b) evaluate its response to the electrophilic nitro-oleic acid (NO2-OA). Regarding LOX-derived products, a significant increase in 12-hydroxyeicosatetraenoic acid (12-HETE) levels was detected in SOD1G93A mice both in plasma and brain whereas no changes were observed in age-matched non-Tg mice at the onset of motor symptoms (90 days-old). In addition, 15-hydroxyeicosatetraenoic acid (15-HETE) levels were greater in SOD1G93A brains compared to non-Tg. Prostaglandin levels were also increased at day 90 in plasma from SOD1G93A compared to non-Tg being similar in both types of animals at later stages ...Continue Reading

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Citations

Jan 9, 2020·Journal of Neural Transmission·David DevosUNKNOWN FAIRPARK-II and FAIRALS-II studygroups
May 12, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Carlos CasasnovasAurora Pujol
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Jan 8, 2020·Data in Brief·Mauricio MastrogiovanniHomero Rubbo
Oct 3, 2020·Prostaglandins & Other Lipid Mediators·Andrés TrostchanskyHomero Rubbo
Apr 11, 2021·The Journal of Nutritional Biochemistry·Beatriz Sánchez-CalvoAndrés Trostchansky
Sep 19, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Proma BasuManuela Martins-Green

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Methods Mentioned

BETA
transgenic

Software Mentioned

Primer of Bioestatistics
Peak View
ImageJ

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