PMID: 1208624Sep 1, 1975Paper

Profile of drug effects on temporally spaced responding in rats

Pharmacology, Biochemistry, and Behavior
K Ando

Abstract

A differential reinforcement of low rate schedule was used with rats to test 15 psychotropic drugs. The computer analysis was based on interresponse time (IRT). Mean IRT, IRT standard deviation, median IRT, IRT midrange, modal IRT, frequency of modal IRT, and an efficiency index, in addition to numbers of responses and reinforcements and the IRT histogram were obtained for each rat in each drug test. An increase in number of responses and a peak shift to shorter IRTs in the histograms were observed with amphetamine, methamphetamine, priradrol and nicotine, as reported by many other investigators. Decrease in IRT midrange and less change in number of responses were observed with diazepam and chlordiazepoxide. Long pauses were found with LSD-25, 2,5-dimethoxy-4-methylamphetamine (DOM) and mescaline. In a factor analysis, the following main factors were obtained. High values in factor loading a1 were observed with chlorpromazine, chlordiazepoxide, pentobarbital, imipramine, nialamide, LSD-25, DOM and mescaline. With these drugs, mean IRT and IRT standard deviation were also high. Values for a2, were high with amphetamine, methamphetamine, pipradrol and nicotine. High a3 values were observed in some rats with chlorpromazine, diazep...Continue Reading

References

Jan 1, 1971·Psychopharmacologia·J B Appel
Mar 11, 1960·Science·I GELLERJ SEIFTER

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Citations

Jan 1, 1992·Psychopharmacology·T J Hudzik, B L Slifer
May 1, 1977·Pharmacology, Biochemistry, and Behavior·J G Canon, A S Lippa
Jul 1, 1978·Pharmacology, Biochemistry, and Behavior·D Webb, T E Levine
May 1, 1978·Pharmacology, Biochemistry, and Behavior·H Kuribara
Dec 1, 1979·Pharmacology, Biochemistry, and Behavior·C C Loullis, M J Wayner
Nov 1, 1980·Pharmacology, Biochemistry, and Behavior·H Kuribara, S Tadokoro
May 1, 1981·Pharmacology, Biochemistry, and Behavior·H E ModrowJ M Carney
Jun 1, 1987·Pharmacology, Biochemistry, and Behavior·R C MichaelisP L Huerta
Mar 14, 2007·Behavioural Pharmacology·Kathryn A SaulsgiverClive D L Wynne
May 1, 1984·Clinical and Experimental Pharmacology & Physiology·V Nalwa, P S Rao
Nov 1, 1996·Journal of Clinical Pharmacology·S A ShappellC A DeJohn
Sep 1, 1991·Journal of the Experimental Analysis of Behavior·J R GlowaA L Riley
Jul 1, 1997·Journal of the Experimental Analysis of Behavior·S H SnodgrassD E McMillan

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