Abstract
Pancreatic cancer has a very poor prognosis as most patients are diagnosed at an advanced stage when curative treatments are not possible. Breath volatile organic compounds (VOCs) have shown potential as novel biomarkers to detect cancer. The aim of the study was to quantify differences in exhaled breath VOCs of patients with pancreatic cancers compared with cohorts without cancer. Patients were recruited to an initial development cohort and a second validation cohort. The cancer group included patients with localized and metastatic cancers, whereas the control group included patients with benign pancreatic disease or normal pancreas. The reference test for comparison was radiological imaging using abdominal CT, ultrasound imaging or endoscopic ultrasonography, confirmed by histopathological examination as appropriate. Breath was collected from the development cohort with steel bags, and from the validation cohort using the ReCIVA™ system. Analysis was performed using gas chromatography-mass spectrometry. A total of 68 patients were recruited to the development cohort (25 with cancer, 43 no cancer) and 64 to the validation cohort (32 with cancer, 32 no cancer). Of 66 VOCs identified, 12 were significantly different between grou...Continue Reading
References
Mar 1, 1993·Pancreas·A von RosenS Pegert
Jun 17, 1999·Lancet·M PhillipsW P McVay
Mar 31, 2004·Lancet·Donghui LiJames L Abbruzzese
Jul 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael Goggins
Feb 28, 2006·Breast Cancer Research and Treatment·Michael PhillipsCynthia Wong
Feb 13, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Diana PoliAntonio Mutti
Apr 28, 2010·PloS One·Shan DengLin Zhang
Mar 9, 2011·Journal of Breath Research·P R BoshierG B Hanna
Apr 9, 2011·Thorax·Piers R BoshierNandor Marczin
Dec 21, 2011·The European Respiratory Journal·Eleanor A ChapmanDeborah H Yates
May 24, 2012·British Journal of Cancer·S StapleyW Hamilton
Dec 6, 2012·The British Journal of Surgery·D F AltomareG de Gennaro
May 11, 2013·Analytical Chemistry·Sacheen KumarGeorge B Hanna
Jul 23, 2013·Cancer Cell International·Paweł MochalskiAnton Amann
Jun 14, 2014·Cancer Research·Anne Marie LennonRalph H Hruban
Oct 17, 2014·Journal of Clinical Gastroenterology·Sheraz R MarkarGeorge B Hanna
Nov 7, 2014·Expert Review of Gastroenterology & Hepatology·Claire JenkinsonEithne Costello
Jan 13, 2015·Annals of Surgery·Sacheen KumarGeorge B Hanna
Jan 8, 2016·BMJ Open·Sheraz R MarkarGeorge B Hanna
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Nov 14, 2017·Gastroenterology·Ramesh P ArasaradnamTatjana Crnogorac-Jurcevic
Dec 2, 2017·Annals of Surgery·Sheraz R MarkarGeorge B Hanna
Citations
Sep 30, 2020·BJS Open·D F AltomareN De Vietro
Oct 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·V LongoM Massaro
Mar 13, 2020·Biology Methods and Protocols·Sajjad JanfazaJavad Zahiri
Feb 6, 2020·Cancer Immunology Research·Nina CorteseFederica Marchesi
Jan 27, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Leonardo PolitiLuigi Perbellini
Jan 6, 2021·Cancers·Damiano CaputoGiulio Caracciolo
Jan 2, 2021·Metabolites·Qing WenGeorge B Hanna
Oct 24, 2020·Clinical and Translational Gastroenterology·Giuseppe FerrandinoVictoria K Snowdon
Apr 15, 2021·BMJ Open·Georgia WoodfieldGeorge B Hanna
Apr 16, 2021·BJS Open·K F H HintzenA Peeters
May 8, 2021·Analytical Methods : Advancing Methods and Applications· Analytical Methods Committee Amctb No
May 18, 2021·Frontiers in Oncology·Yoon Ju JungHan Hong Lee
Mar 25, 2021·Journal of Breath Research·Natalia DrabińskaBen De Lacy Costello
Aug 26, 2021·MethodsX·Adrian Vicent-Claramunt, Evaldas Naujalis