Profile of gastrointestinal damage induced by platelet-activating factor

Prostaglandins
J L Wallace, B J Whittle

Abstract

The ulcerogenic actions of an intravenous infusion of platelet-activating factor (100 ng/kg/min) was studied in the rat. Damage to the stomach, duodenum, jejunum, ileum and colon were assessed histologically and using intraluminal acid phosphatase release as a marker of cellular damage. A 10-min infusion of platelet-activating factor caused extensive haemorrhagic damage to each of the regions examined, with the exception of the colon. Acid phosphatase release was significantly elevated in the stomach, jejunum, ileum (p less than 0.001) and duodenum (p less than 0.01), but not in the colon. These studies demonstrate that platelet-activating factor is a potent ulcerogen in the stomach and small intestine, and support a role for this endogenous phospholipid as a mediator of the ulceration associated with endotoxin-induced shock.

References

Sep 1, 1985·Digestive Diseases and Sciences·J L WallaceN K Boughton-Smith
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May 1, 1972·Annals of Surgery·W A AltemeierJ J McDonough
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Citations

Feb 1, 1988·Digestive Diseases and Sciences·J L Wallace, B J Whittle
Nov 1, 1996·Digestive Diseases and Sciences·R Hernández-Muñoz, F Montiel-Ruíz
Dec 1, 1995·Digestive Diseases and Sciences·R GuimbaudS Chaussade
Apr 1, 1992·Gastroenterologia Japonica·A Terano
Jun 22, 1988·European Journal of Pharmacology·J L Wallace, W K MacNaughton
Feb 9, 1993·European Journal of Pharmacology·J DamasV Bourdon
Mar 1, 1992·The Journal of Pharmacy and Pharmacology·A PintoF Capasso
Aug 1, 1992·The Journal of Pharmacy and Pharmacology·N MascoloF Capasso
Feb 1, 1987·Pharmacological Research Communications·A BrambillaA Giachetti
Nov 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J SugataniK Saito
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·S J Konturek
Sep 1, 1990·Scandinavian Journal of Gastroenterology·Z AckermanD Rachmilewitz
Nov 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F GuarnerJ Rodés
Oct 13, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Guo-Du WangYun Xia
Aug 1, 1992·Stroke; a Journal of Cerebral Circulation·K SatohS Mizuno
Dec 13, 2019·Oxidative Medicine and Cellular Longevity·Lady D K T PrazeresAlmir G Wanderley
Sep 1, 1987·British Journal of Pharmacology·B J WhittleJ L Wallace
Nov 1, 1996·The Journal of Pharmacy and Pharmacology·A A Izzo
Oct 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P V Peplow, D P Mikhailidis

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