Profile of human β-defensins 1,2 and proinflammatory cytokines (TNF-α, IL-6) in patients with chronic kidney disease

Kidney & Blood Pressure Research
Dong-Jin OhYo Seop Woo

Abstract

Our aim was to determine whether altered human β-defensin (HBD), pro-inflammatory cytokines including interleukin (IL)-6 and tumor necrotic factor (TNF)-α could increase the risk of developing and exacerbation of chronic kidney disease (CKD), especially for patients with diabetic nephropathy (DN). Serum samples were obtained from 338 CKD patients and 88 sex, age-matched healthy controls. The concentrations of HBD-1 were assayed using an RIA kit. Serum levels of HBD-2, IL-6 and TNF-α were assayed using an ELISA kit. Serum levels of HBD-1, IL-6 and TNF-α were significantly higher in CKD patients compared to healthy controls (P<0.05). HBD-1 levels were inversely related to estimated glomerular filtration rate (eGFR), which was the coefficient factor (β = -0.357, P = 0.035) explaining the variability in HBD-1 in CKD. Diabetic nephropathy (DN) patients at stage 3-5 had significantly higher serum HBD-1 levels than non DN patients (P=0.00). Our data support the view that there is increased inflammation in CKD and DN. The inverse correlation between eGFR and serum HBD-1 which we observed is suggestive of a relationship between innate immunity and renal function and should be further investigated.

Citations

Feb 10, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Li FanLi-Hua Chen
Nov 17, 2015·Nature Reviews. Nephrology·Jun Wada, Hirofumi Makino
Apr 23, 2016·Medicine·Yuh-Shin ChangRen-Long Jan
Sep 27, 2016·Disease Markers·Simona MihaiCristiana Tanase
Feb 23, 2020·Oxidative Medicine and Cellular Longevity·Dania HaddadFahd Al-Mulla
Aug 28, 2019·Canadian Journal of Kidney Health and Disease·Samuel A Silver, Casimiro Gerarduzzi
Nov 14, 2020·International Journal of Molecular Sciences·Carmen J Pastor-MaldonadoJosé A Sánchez-Alcázar
Jul 13, 2021·Immunological Investigations·Luis Antonio Ochoa-RamirezJesús Salvador Velarde-Felix
Sep 12, 2017·Kidney International·Liyu HeZheng Dong

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