Profile of patients with inflammatory bowel disease in conjunction with unmet needs and decision-making for choosing a new biologic therapy: a baseline analysis of the VEDOIBD-Study.

International Journal of Colorectal Disease
Romina di GiuseppeStefan Schreiber

Abstract

We characterized the profile of Crohn's disease (CD) or ulcerative colitis (UC) biologic-naïve patients (starting a new therapy with vedolizumab or TNFα-antagonists), their baseline disease activity predictors, and their perception of the quality of life (HRQoL). The VEDOIBD-Study is a real-world study on the effectiveness of vedolizumab vs other biologics as induction and maintenance therapy for CD and UC. A total of 627 CD and 546 UC patients were enrolled from IBD-experienced centers across Germany. In both biologic-naïve vedolizumab (n=397) and anti-TNF (n=359) patients, CD and UC disease severity and HRQoL predictors were analyzed with logistic regression. The results were reported as odds ratio (OR) and 95% confidence interval (CI). When compared to biologic-naïve anti-TNF patients, a first biological therapy with vedolizumab was considered for older CD patients, with a less complicated though longer disease course, and with a history of comorbidities. No differences in (unmet) needs were observed among patients with UC. The presence of extra-intestinal manifestations in biologic-naïve anti-TNF patients with CD (OR (95% CI): 3.83 (1.69-8.68)) and, in both biologic-naïve groups of patients with UC, stool frequency (2.00 (1...Continue Reading

References

Jun 6, 1996·Health Policy·R Brooks
Jan 24, 2003·Zeitschrift für Gastroenterologie·E F StangeUNKNOWN German Society for Digestive and Metabolic Diseases
Feb 17, 2006·Gut·E F StangeUNKNOWN European Crohn's and Colitis Organisation
Nov 30, 2007·The New England Journal of Medicine·Jerry Avorn
Jul 2, 2009·Deutsches Ärzteblatt International·Daniel C Baumgart
Dec 15, 2010·Computer Methods and Programs in Biomedicine·Alan C Elliott, Linda S Hynan
Mar 1, 2008·Journal of Crohn's & Colitis·E F StangeUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Jun 8, 2011·Gut·Laurent Peyrin-BirouletUNKNOWN International Programme to Develop New Indexes for Crohn's Disease (IPNIC) group
Aug 24, 2013·The New England Journal of Medicine·Brian G FeaganUNKNOWN GEMINI 1 Study Group
Aug 24, 2013·The New England Journal of Medicine·William J SandbornUNKNOWN GEMINI 2 Study Group
Sep 18, 2014·Nestlé Nutrition Institute Workshop Series·Jean-Frédéric Colombel
May 29, 2015·Zeitschrift für Gastroenterologie·S SchreiberB Bokemeyer
Feb 20, 2016·Gut·Jean-Frédéric ColombelBrian G Feagan
Mar 6, 2016·Journal of Crohn's & Colitis·Julia SalleronLaurent Peyrin-Biroulet
Sep 5, 2018·Health Care Analysis : HCA : Journal of Health Philosophy and Policy·Lars Sandman, Björn Hofmann
Nov 14, 2018·Intestinal research·Prisca Yue Min HoWan Chee Ong
Jul 10, 2019·Zeitschrift für Gastroenterologie·Alina BrandesBernd Bokemeyer
Mar 18, 2020·Drugs in Context·Benjamin CrooksJimmy K Limdi
Apr 7, 2020·Diabetes, Obesity & Metabolism·Yoon Kong Loke, Katharina Mattishent
Apr 7, 2020·Diabetes, Obesity & Metabolism·Colin P O'Leary, Matthew A Cavender
Apr 28, 2020·BMJ Open Gastroenterology·Ignacio Marin-JimenezManuel Barreiro-de Acosta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.