Profile of resistance of human immunodeficiency virus to mannose-specific plant lectins.

Journal of Virology
Jan BalzariniDominique Schols

Abstract

The mannose-specific plant lectins from the Amaryllidaceae family (e.g., Hippeastrum sp. hybrid and Galanthus nivalis) inhibit human immunodeficiency virus (HIV) infection of human lymphocytic cells in the higher nanogram per milliliter range and suppress syncytium formation between persistently HIV type 1 (HIV-1)-infected cells and uninfected CD4(+) T cells. These lectins inhibit virus entry. When exposed to escalating concentrations of G. nivalis and Hippeastrum sp. hybrid agglutinin, a variety of HIV-1(III(B)) strains were isolated after 20 to 40 subcultivations which showed a decreased sensitivity to the plant lectins. Several amino acid changes in the envelope glycoprotein gp120, but not in gp41, of the mutant virus isolates were observed. The vast majority of the amino acid changes occurred at the N glycosylation sites and at the S or T residues that are part of the N glycosylation motif. The degree of resistance to the plant lectins was invariably correlated with an increasing number of mutated glycosylation sites in gp120. The nature of these mutations was entirely different from that of mutations that are known to appear in HIV-1 gp120 under the pressure of other viral entry inhibitors such as dextran sulfate, bicyclam...Continue Reading

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Citations

Jul 17, 2007·Nature Reviews. Microbiology·Jan Balzarini
Oct 19, 2011·The Journal of Biological Chemistry·Katrien O François, Jan Balzarini
Sep 15, 2010·Antimicrobial Agents and Chemotherapy·Suzanne J F KapteinJohan Neyts
Jul 9, 2010·Journal of Virology·Elizabeth Stansell, Ronald C Desrosiers
May 19, 2007·Retrovirology·Hongying ChenIan M Jones
Sep 28, 2005·Expert Opinion on Investigational Drugs·Kurt Vermeire, Dominique Schols
Jun 7, 2005·Expert Opinion on Emerging Drugs·Erik De Clercq
Aug 30, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hui LvJin-Ku Bao
Jul 5, 2008·The International Journal of Biochemistry & Cell Biology·Dana HuskensDominique Schols
Sep 22, 2007·Advanced Drug Delivery Reviews·H ZappeM J Bossard
Jun 26, 2010·Medicinal Research Reviews·K O François, J Balzarini
Mar 30, 2006·Antiviral Research·J Balzarini
Aug 30, 2005·Current Opinion in Microbiology·Erik De Clercq
Oct 1, 2013·Virology·Kabamba B AlexandreLynn Morris
Mar 1, 2015·Expert Opinion on Therapeutic Targets·Priyamvada AcharyaPeter D Kwong
Nov 6, 2013·FEMS Microbiology Reviews·Wander Van BreedamHans J Nauwynck
Feb 24, 2015·The Journal of Antimicrobial Chemotherapy·Stephanie C GordtsDominique Schols
Dec 8, 2014·Biochemical Pharmacology·Erik De Clercq
Oct 29, 2005·The Lancet Infectious Diseases·Jan Balzarini
Nov 27, 2018·Journal of Food Protection·Sang-Mu KoDuwoon Kim

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