Profile of stress and toxicity gene expression in human hepatic cells treated with Efavirenz

Antiviral Research
Leysa J Gomez-SucerquiaNadezda Apostolova

Abstract

Hepatic toxicity and metabolic disorders are major adverse effects elicited during the pharmacological treatment of the human immunodeficiency virus (HIV) infection. Efavirenz (EFV), the most widely used non-nucleoside reverse transcriptase inhibitor (NNRTI), has been associated with these events, with recent studies implicating it in stress responses involving mitochondrial dysfunction and oxidative stress in human hepatic cells. To expand these findings, we analyzed the influence of EFV on the expression profile of selected stress and toxicity genes in these cells. Significant up-regulation was observed with Cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), which indicated metabolic stress. Several genes directly related to oxidative stress and damage exhibited increased expression, including Methalothionein 2A (MT2A), Heat shock 70kDa protein 6 (HSPA6), Growth differentiation factor 15 (GDF15) and DNA-damage-inducible transcript 3 (DDIT3). In addition, Early growth response protein 1 (EGR1) was enhanced, whereas mRNA levels of the inflammatory genes Chemokine (C-X-C motif) ligand 10 (CXCL10) and Serpin peptidase inhibitor (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1) decreased and increas...Continue Reading

References

Jan 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Roberto ManfrediFrancesco Chiodo
Nov 4, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Félix GutiérrezAlberto Martín-Hidalgo
Dec 21, 2005·Journal of Hepatology·Marina Núñez
Jun 27, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S TsuchihashiJ W Kupiec-Weglinski
Oct 13, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Xin Hao ZhuYen Wah Tong
Sep 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·X-D ShenJ W Kupiec-Weglinski
Jan 31, 2008·Cell Stress & Chaperones·Emily J NoonanLawrence E Hightower
Aug 12, 2008·Current Drug Safety·Ira Inductivo-Yu, Maurizio Bonacini
Sep 23, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Dong Yeok ShinYung Hyun Choi
Jun 18, 2009·BMC Cancer·Vasilis P AndroutsopoulosDemetrios A Spandidos
Sep 22, 2009·The Journal of Antimicrobial Chemotherapy·Franco Maggiolo
Apr 20, 2010·Trends in Molecular Medicine·Martine Caron-DebarleJacqueline Capeau
Jun 22, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ana Blas-GarcíaJuan V Esplugues
Sep 3, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marina Núñez
Oct 5, 2010·Chemico-biological Interactions·Panagiotis Mitsopoulos, Zacharias E Suntres
Nov 5, 2010·Journal of Cell Science·Cole M Haynes, David Ron
Jan 15, 2011·The Biochemical Journal·Jurre HagemanHarm H Kampinga
Jun 1, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nadezda ApostolovaJuan V Esplugues

❮ Previous
Next ❯

Citations

Nov 6, 2012·The Journal of Infectious Diseases·Charlotte V HobbsPhotini Sinnis
Mar 30, 2013·The Journal of Infectious Diseases·Charlotte V HobbsPatrick E Duffy
Jan 21, 2014·Environmental Toxicology and Pharmacology·Hugo Martins de OliveiraVanessa M Andrade
Sep 10, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Gbenga Anthony AdefolajuMargot Jill Hosie
Feb 14, 2014·European Journal of Endocrinology·Suman Srinivasa, Steven K Grinspoon
May 14, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Pere DomingoMarta Giralt
Feb 11, 2015·Cardiovascular Toxicology·Marlene WeißAnsgar Brüning
May 2, 2014·Journal of Gastroenterology and Hepatology·Urs A Boelsterli, Kang Kwang Lee
Jun 26, 2013·Journal of Hepatology·Nadezda ApostolovaJuan V Esplugues
Jan 28, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·T M StępkowskiM Kruszewski
Nov 5, 2013·Virus Research·Christophe FraisierChristophe Nicolas Peyrefitte
Mar 7, 2014·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Si ChenLei Guo
Oct 18, 2019·Expert Opinion on Drug Metabolism & Toxicology·Natalia A JungmannMichael Gerisch
Mar 4, 2020·Journal of Medicinal Food·Blanca Patricia Lazalde-RamosGabriela Morales-Velazquez
Aug 18, 2020·Journal of Pediatric Gastroenterology and Nutrition·Junwei SuUNKNOWN CHANGES Bone Study Team
Apr 24, 2019·Asian-Australasian Journal of Animal Sciences·Doh Hoon KimYoung Mok Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Nadezda ApostolovaJuan V Esplugues
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Ana Blas-GarciaJuan V Esplugues
© 2021 Meta ULC. All rights reserved