PMID: 20118632Feb 2, 2010Paper

Profiles of Chemical Effects on Cells (pCEC): a toxicogenomics database with a toxicoinformatics system for risk evaluation and toxicity prediction of environmental chemicals

The Journal of Toxicological Sciences
Hideko SoneJunzo Yonemoto

Abstract

Profiles of Chemical Effects on Cells (pCEC) is a toxicogenomics database with a system of classifying chemicals that have effects on human health. This database stores and handles gene expression profiling information and categories of toxicity data. Chemicals are classified according to the specific tissues and cells they affect, the gene expression changes they induce, their toxicity and biological functions in this database system. The pCEC system also analyzes relationships between chemicals and the genes they affect in specific tissues and cells. The reason why we developed pCEC is to support decision-making within the context of environmental regulation. Especially, exposure to environmental chemicals during fetal and newborn development may result in a predisposition to various disorders such as cancer, learning disabilities and allergies later in life. The identification and prediction of hazardous chemicals using limited information are important issues in human health risk management. Therefore, various toxicity information including lethal dose 50 (LD50), toxicity pathways and pathological data were loaded into pCEC. pCEC is also a facility for query, analysis and prediction of unknown toxicochemical reaction pathwa...Continue Reading

References

Jun 17, 1999·FEBS Letters·P TörönenE Castrén
Jan 24, 2002·Mutation Research·Marilyn J Aardema, James T MacGregor
Dec 4, 2003·Mutation Research·Michael D WatersRaymond W Tennant
Dec 2, 2004·Nature Reviews. Genetics·Michael D Waters, Jennifer M Fostel
Dec 21, 2004·Nucleic Acids Research·Tanya BarrettRon Edgar
Mar 11, 2005·Alternatives to Laboratory Animals : ATLA·Julia FentemBart Sangster
May 11, 2006·Neurotoxicology·Philip J BushnellVernon A Benignus
Sep 23, 2006·Nature Reviews. Cancer·Robert H Shoemaker
Nov 14, 2006·Nucleic Acids Research·Tanya BarrettRon Edgar
Mar 17, 2007·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Romualdo BenigniChihae Yang
Dec 11, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Robert J KavlockEric Weber
Jun 24, 2008·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Richard Y Wang
Aug 2, 2008·Toxicology and Applied Pharmacology·Richard JudsonMaritja Wolf
Aug 5, 2008·Toxicology and Applied Pharmacology·Michael Waters, Marcus Jackson
Sep 27, 2008·Environmental Science and Pollution Research International·Jan AhlersBarbara Werschkun
Oct 22, 2008·Nucleic Acids Research·Joel MasciocchiStefano Moro
Nov 11, 2008·Toxicology Letters·Carolyn J Mattingly
Nov 14, 2008·Nucleic Acids Research·Ulrike SchmidtRobert Preissner
Nov 26, 2008·Alternatives to Laboratory Animals : ATLA·Gavin MaxwellCarl Westmoreland
Dec 6, 2008·Environmental Health Perspectives·Tracey J WoodruffR Thomas Zoeller
Dec 17, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Melvin E Andersen, Daniel Krewski
Jan 16, 2009·Risk Analysis : an Official Publication of the Society for Risk Analysis·Daniel KrewskiLauren Zeise
Jan 23, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Carine B LambertAndre Guillouzo
Apr 1, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·ClarLynda R Williams-DevaneAnn M Richard
May 30, 2009·Toxicology Letters·Klaus SchneiderSebastian Hoffmann
May 30, 2009·Environmental Health Perspectives·Richard JudsonEdwin Smith
Jan 12, 2010·Human & Experimental Toxicology·Robert F Phalen

❮ Previous
Next ❯

Citations

Dec 15, 2010·International Journal of Molecular Sciences·Balam Muñoz, Arnulfo Albores
Nov 13, 2013·Drug Discovery Today·Saifur R KhanArno G Siraki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

© 2021 Meta ULC. All rights reserved