Profiles of cortical inflammation in multiple sclerosis by 11C-PBR28 MR-PET and 7 Tesla imaging.

Multiple Sclerosis : Clinical and Laboratory Research
Elena HerranzCaterina Mainero

Abstract

Neuroinflammation with microglia activation is thought to be closely related to cortical multiple sclerosis (MS) lesion pathogenesis. Using 11C-PBR28 and 7 Tesla (7T) imaging, we assessed in 9 relapsing-remitting multiple sclerosis (RRMS) and 10 secondary progressive multiple sclerosis (SPMS) patients the following: (1) microglia activation in lesioned and normal-appearing cortex, (2) cortical lesion inflammatory profiles, and (3) the relationship between neuroinflammation and cortical integrity. Mean 11C-PBR28 uptake was measured in focal cortical lesions, cortical areas with 7T quantitative T2* (q-T2*) abnormalities, and normal-appearing cortex. The relative difference in cortical 11C-PBR28 uptake between patients and 14 controls was used to classify cortical lesions as either active or inactive. Disease burden was investigated according to cortical lesion inflammatory profiles. The relation between q-T2* and 11C-PBR28 uptake along the cortex was assessed. 11C-PBR28 uptake was abnormally high in cortical lesions in RRMS and SPMS; in SPMS, tracer uptake was significantly increased also in normal-appearing cortex. 11C-PBR28 uptake and q-T2* correlated positively in many cortical areas, negatively in some regions. Patients with ...Continue Reading

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Citations

Nov 19, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Tammy T HshiehUNKNOWN RISE Study Group
Apr 21, 2020·Expert Review of Neurotherapeutics·Eleonora TavazziNiels Bergsland
May 28, 2020·ELife·Jennifer Orthmann-MurphyDwight E Bergles
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Aug 17, 2021·Radiologic Clinics of North America·Christian MasonJason S Lewis

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Software Mentioned

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house
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