Profiles of human milk oligosaccharides and production of some human milk oligosaccharides in transgenic animals.

Advances in Nutrition
P Prieto

Abstract

During the decade of the 1990s and the first years of the current century, our group embarked on a project to study and synthesize human milk oligosaccharides. This report describes 2 unexpected collateral observations from that endeavor. The first observation was the detection and confirmation of 2 rare neutral human milk oligosaccharides profiles that were uncovered while assessing oligosaccharide content in hundreds of samples of human milk. One of these lacked fucosylated structures altogether, and the other lacked the oligosaccharide 3-fucosyllactose [Galβ1-4(Fucα1-3)Glc]. We used glycoconjugate probes to determine whether the unusual profiles were mirrored by fucosylation of milk glycoproteins. The results show that the lack of fucosylated oligosaccharides in these samples corresponds to the absence of equivalent fucosylated motifs in milk glycoproteins. The second finding was a shortened and distinct lactation process in transgenic rabbits expressing the human fucosyltransferase 1. During the first day of lactation, these animals expressed milk that contained both lactose and 2'-fucosylactose, but on the second day, the production of milk was severely diminished, and by the fourth day, no lactose was detected in their mi...Continue Reading

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Citations

May 16, 2012·Advances in Nutrition·Clemens KunzSharon M Donovan
Nov 20, 2013·Nutrition Reviews·Esther Castanys-MuñozPedro Antonio Prieto
Sep 1, 2015·Glycoconjugate Journal·Jolanta Lis-KuberkaMagdalena Orczyk-Pawiłowicz
Dec 3, 2014·Clinical Biochemistry·Magdalena Orczyk-PawiłowiczIwona Kątnik-Prastowska
Sep 8, 2016·Journal of Pediatric Gastroenterology and Nutrition·Clemens KunzSilvia Rudloff
Mar 13, 2014·Advances in Nutrition·Francesco Visioli, Andrea Strata
Jun 11, 2014·Beneficial Microbes·S MusilovaV Bunesova
Dec 1, 2017·Journal of Food Engineering·Leticia F M C AquinoDaniela Barile
Jun 19, 2018·Journal of Agricultural and Food Chemistry·M ElwakielH A Schols

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