Profiles of IgE Sensitization to Der f 1, Der f 2, Der f 6, Der f 8, Der f 10, and Der f 20 in Korean House Dust Mite Allergy Patients

Allergy, Asthma & Immunology Research
Kyoung Yong JeongJung Won Park

Abstract

Measurement of IgE specific to purified house dust mite (HDM) allergens may improve allergy diagnosis. This study aimed to investigate the sensitization profiles of Korean HDM allergic subjects suffering from respiratory allergy and atopic dermatitis (AD) to Der f 1, Der f 2, Der f 6, Der f 8, Der f 10, and Der f 20. Recombinant HDM allergens were produced in Pichia pastoris (Der f 1) or Escherichia coli (5 allergens). IgE reactivity to the individual recombinant allergens and total extract of mite was assessed by ELISA. Der f 1 was recognized by 79.1%, Der f 2 by 79.1%, Der f 6 by 9.3%, Der f 8 by 6.2%, Der f 10 by 6.2%, and Der f 20 by 6.6% of the patients' sera tested, while the prevalence of IgE reactivity to total mite extract was 94.7%. Combination of Der f 1 and Der f 2 had a sensitivity of 87.6%. Specific IgE to Der f 2 alone was detected from 89.4% of HDM-sensitized respiratory allergy subjects and 92.3% to the combination of the 2 major allergens Der f 1 and Der f 2. However, sera from fewer patients with AD, namely 72.4% and 71.0%, recognized Der f 1 and Der f 2, respectively. The combination of 2 major allergens allowed diagnosis of 84.5% of the AD patients. No correlation between sensitization to specific allergens...Continue Reading

References

Jun 26, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R ValentaH Grönlund
Feb 13, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T YasuharaY Okumura
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M BinderM Duchêne
Apr 15, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G PittnerR Valenta
Sep 1, 2005·Current Opinion in Allergy and Clinical Immunology·L Karla Arruda, Ana Beatriz R Santos
Nov 1, 2006·Protein and Peptide Letters·Kyoung Yong JeongTai-Soon Yong
Jun 23, 2007·Protein and Peptide Letters·Kyoung Yong JeongTai-Soon Yong
Sep 12, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B J HalesW R Thomas
Jan 29, 2008·Protein and Peptide Letters·Wayne Robert ThomasBelinda Joy Hales
Feb 16, 2008·The Journal of Allergy and Clinical Immunology·Ana Beatriz R SantosL Karla Arruda
Nov 22, 2008·European Journal of Clinical Investigation·M WeghoferS Vrtala
Feb 22, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Mona I KidonChew Fook Tim
Jun 30, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y ReschS Vrtala
Apr 27, 2012·Experimental & Applied Acarology·Kyoung Yong JeongJung-Won Park
May 1, 2012·The Journal of Allergy and Clinical Immunology·Helton C SantiagoThomas B Nutman
Oct 19, 2012·Current Allergy and Asthma Reports·Regina Treudler, Jan C Simon
Nov 2, 2012·Allergy, Asthma & Immunology Research·Kyoung Yong JeongChein-Soo Hong
Nov 2, 2012·Allergy, Asthma & Immunology Research·Kyoung Yong JeongJung-Won Park
Mar 6, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Margit WeghoferSusanne Vrtala
May 21, 2014·Allergy, Asthma & Immunology Research·Kyoung Yong JeongJung-Won Park

❮ Previous
Next ❯

Citations

Jan 13, 2016·Journal of Proteome Research·Jintarat ChoopongAnchalee Tungtrongchitr
Oct 5, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Wayne R Thomas
Sep 11, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Hendrik NolteMirko Bollen
Sep 8, 2016·Current Allergy and Asthma Reports·Wayne R Thomas
Aug 18, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L-H MoP-C Yang
Apr 28, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K H ParkJ-W Park
Dec 8, 2019·Science Immunology·Kazumasa KanemaruYoshiyuki Nakamura
Jan 9, 2020·Expert Opinion on Therapeutic Patents·Eduardo Santos da SilvaNeuza Maria Alcantara-Neves
Aug 1, 2019·Current Protein & Peptide Science·Nitat SookrungWanpen Chaicumpa
Apr 22, 2017·Current Allergy and Asthma Reports·Daniela PosaPaolo Maria Matricardi
Feb 25, 2017·Allergy·J F CantilloE Fernández-Caldas
Jul 3, 2021·Allergy, Asthma & Immunology Research·Ji Tae KimJung Won Park

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

SPSS

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
H D ShenW R Thomas
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
R FerrándizS Dreborg
© 2022 Meta ULC. All rights reserved