Profiles of inflammatory markers and lipoprotein subclasses in patients undergoing continuous ambulatory peritoneal dialysis

Clinica Chimica Acta; International Journal of Clinical Chemistry
Mika KonTakashi Miida

Abstract

Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) often have inflammation and dyslipidemia that accelerate to atherosclerosis. This study aimed to evaluate chronic inflammation and dyslipidemia in CAPD patients. We measured inflammatory markers and lipoprotein subclasses in 20 CAPD patients (12 men and 8 women, aged 59.5 ± 9.9 y) and 20 gender-matched controls. Lipoproteins were separated by high-performance liquid chromatography (HPLC) using an anion-exchange column. High-sensitivity C-reactive protein and serum amyloid A protein (SAA) were higher among CAPD patients vs. controls (1.6 ± 2.2 vs. 0.8 ± 1.2 mg/l, p<0.05; 11.9 ± 12.8 vs. 4.5 ± 2.4 mg/l). HPLC analysis revealed that chylomicron, VLDL, and IDL cholesterol levels were higher among CAPD vs. controls. In contrast, HDL cholesterol was lower among CAPD patients vs. controls. In the subgroup analysis, SAA levels were significantly lower among patients receiving CAPD for >3 y than among controls. However, IDL cholesterol was consistently higher among CAPD patients vs. controls. CAPD patients have chronic inflammation and dyslipidemia. IDL cholesterol is the only lipoprotein subclass that is consistently elevated regardless of CAPD duration. More attentio...Continue Reading

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Citations

Jul 13, 2011·International Journal of Nephrology·Jana UhlinovaMai Ots-Rosenberg
Oct 19, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mayumi IdeiTakashi Miida
Mar 29, 2014·The Cochrane Database of Systematic Reviews·Yeoungjee ChoKathryn J Wiggins
Sep 25, 2019·Journal of Atherosclerosis and Thrombosis·Yuji Hirowatari, Hiroshi Yoshida

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