Profiles of novel diurnally regulated genes in mouse hypothalamus: expression analysis of the cysteine and histidine-rich domain-containing, zinc-binding protein 1, the fatty acid-binding protein 7 and the GTPase, ras-like family member 11b

Neuroscience
J R GerstnerC F Landry

Abstract

Gene expression profiling of suprachiasmatic nucleus, ventrolateral preoptic area and the lateral hypothalamus was used to identify genes regulated diurnally in the hypothalamus of Mus musculus. The putative transcription regulator, cysteine and histidine-rich domain-containing, zinc binding protein 1, which had not been previously described in brain, was found to cycle diurnally in hypothalamus and forebrain with peak levels of mRNA expression during the dark phase. mRNA for the brain-type fatty acid binding protein 7 was found to change rhythmically in hypothalamic and extra-hypothalamic brain regions reaching peak levels early in the light phase suggesting that lipid metabolism is under circadian regulation in astrocytes. Rhythmically expressed genes in suprachiasmatic nucleus identified here were compared with previous reports in a meta-analysis. Genes held in common included fabp7, and the period gene, Per2. Also identified were genes implicated in guanosine-mediated signaling pathways that included dexamethasone-induced ras-related protein one (dexras1), regulator of G-protein signaling (rgs) 16, and ras-like family member 11b. Northern blotting confirmed diurnal changes in mRNA expression in the hypothalamus for these ge...Continue Reading

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Citations

Jan 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason R GerstnerCharles F Landry
May 13, 2014·International Journal of Cell Biology·Ashish ThapliyalNavin Kumar
Jun 11, 2008·Journal of Neuroscience Research·Peter GassPeter J Gebicke-Haerter
Jun 21, 2016·Journal of Neuroscience Research·Jason R GerstnerAllan I Pack
Jul 22, 2010·Nature Reviews. Neuroscience·Jason R Gerstner, Jerry C P Yin
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Oct 19, 2006·Developmental Neuroscience·Jason R Gerstner, Charles F Landry
Feb 28, 2018·Frontiers in Physiology·Donají Chi-Castañeda, Arturo Ortega
Jun 1, 2021·Current Research in Neurobiology·William M VanderheydenJason R Gerstner

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