Profiling 1,25-dihydroxyvitamin D3-regulated gene expression by microarray analysis

The Journal of Steroid Biochemistry and Molecular Biology
John H White

Abstract

Vitamin D was discovered as a preventive agent of nutritional rickets, a defect in bone development due to inadequate uptake of dietary calcium. However, a variety of studies over the last several years has revealed that Vitamin D controls much more than calcium homeostasis. In particular, there is widespread evidence that the hormonal form of Vitamin D, 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is an important regulator of cellular differentiation and proliferation. Direct genomic signaling by 1,25(OH)(2)D(3) occurs through the Vitamin D receptor, which is a nuclear receptor and a ligand-activated regulator of gene transcription. 1,25(OH)(2)D(3) can therefore directly regulate patterns of gene expression within a target cell. The development of high throughput genomics technologies have greatly enhanced our capacity to identify the genetic and biochemical changes associated with the physiological actions of 1,25(OH)(2)D(3). Microarray analyses of expression profiles in 1,25(OH)(2)D(3)-treated cells have underlined its widespread effects on cellular differentiation and proliferation. They have provided a molecular basis for the accumulating epidemiological and preclinical evidence indicating that 1,25(OH)(2)D(3) can ac...Continue Reading

References

May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A R BakerB W O'Malley
Apr 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S M LippmanW K Hong
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M T CantornaH F DeLuca
Apr 1, 1997·The Journal of Clinical Investigation·Z Y LiuJ E Groopman
Aug 20, 1997·Journal of the National Cancer Institute·X WangG P Studzinski
Oct 28, 1998·Physiological Reviews·G JonesH F DeLuca
Oct 3, 1999·Nature Genetics·M C HollanderA J Fornace
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G Penna, L Adorini
Mar 23, 2000·The Journal of Experimental Medicine·M J TownsendA N McKenzie
Aug 23, 2000·British Journal of Cancer·S IkematsuT Muramatsu
Mar 10, 2001·Biochemical and Biophysical Research Communications·N AkutsuJ H White
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·M Ramos-GomezT W Kensler
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·K Z GuytonG H Posner
May 17, 2001·Journal of the National Cancer Institute·J PrudencioJ H White
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·D K PandaD Goltzman
Jun 28, 2001·Physiological Reviews·A Aranda, A Pascual
Apr 16, 2002·The British Journal of Dermatology·J MasonM J Cork
Apr 17, 2002·The Journal of Clinical Investigation·James O'KellyH Phillip Koeffler
May 7, 2002·The Journal of Biological Chemistry·Lionel DrocourtMarie-José Vilarem
Dec 10, 2002·Biochemical and Biophysical Research Communications·Paul D ThompsonMark R Haussler
Jan 10, 2003·Journal of Cellular Biochemistry·Aruna V KrishnanDavid Feldman
Apr 17, 2003·Endocrinology·Francesca GalbiatiAlberto M Davalli
Aug 2, 2003·Breast Cancer Research and Treatment·Srilatha SwamiDavid Feldman

❮ Previous
Next ❯

Citations

Oct 28, 2009·Nature Reviews. Nephrology·Carolina R C DoorenbosMartin H de Borst
Feb 26, 2011·Omics : a Journal of Integrative Biology·Paola MutiSabrina Strano
Jun 27, 2008·Transplantation·Didier DuclouxJean-Marc Chalopin
Dec 5, 2008·Nutrition Reviews·Sam Samuel, Michael D Sitrin
Mar 23, 2010·The Journal of Steroid Biochemistry and Molecular Biology·John H White
Oct 2, 2007·Dermatologic Clinics·Carsten Carlberg, Sabine Seuter
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John S AdamsMartin Hewison
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Glenville JonesHugh Lj Makin
Oct 1, 2011·Journal of Cellular Biochemistry·Paola TarroniAlessandro Rubinacci
Apr 16, 2010·Annals of the New York Academy of Sciences·David Goltzman
Jul 9, 2005·Trends in Endocrinology and Metabolism : TEM·Ricardo BolandAna Russo De Boland
Mar 6, 2012·Molecular and Cellular Endocrinology·Qiuhong ZhangPamela A Hershberger
Oct 3, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Qiuhong ZhangPamela Hershberger
Aug 5, 2009·Critical Reviews in Clinical Laboratory Sciences·Elzbieta Gocek, George P Studzinski
Feb 21, 2009·Social Studies of Science·Anne Fausto-Sterling
May 18, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Gerard E Mullin, Adrian Dobs
Jul 25, 2006·Nuclear Receptor Signaling·Luz E Tavera-MendozaJohn H White
May 19, 2006·International Journal of Cancer. Journal International Du Cancer·Robert A ParisePamela A Hershberger
Jun 30, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Adrian F GombartH Phillip Koeffler
May 19, 2012·Expert Review of Anticancer Therapy·Paulina SzyszkaAndrzej T Slominski
Sep 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hyo-Jung KwonInpyo Choi
May 2, 2006·Molecular Cancer Therapeutics·Sonoko Masuda, Glenville Jones
Aug 9, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Quang T Luong, H Phillip Koeffler

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