Profiling cancer stem cells using protein array technology

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Satoshi Nishizuka

Abstract

Since cancer cells and somatic stem cells share the biological characteristics of self-renewal and proliferation, it has been suggested that the principles of stem cell biology can be applied to improve our understanding of cancer biology. Recent studies have shown that the majority of cancers appear to originate from a small subset of cells that have the ability of self-renewal and to proliferate, namely 'cancer stem cells'. The isolation of cancer stem cells has been demonstrated using cell surface markers in haematopoietic and non-haematopoietic malignancies. Advances in protein array technologies have enabled the use of minuscule amounts of biological materials to profile these cells at the molecular level. Using a combination of protein arrays and cancer stem cell isolation techniques, a higher resolution molecular profiling can be performed, which might improve therapies targeting the cancer stem cells.

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Citations

Nov 1, 2008·Nature Protocols·Brett SpurrierSatoshi Nishizuka
Feb 24, 2011·Molecular Cancer·Sandra Kraljevic PavelicKresimir Pavelic
Oct 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jiangbing ZhouYing Zhang
Jan 30, 2016·Drug Metabolism and Pharmacokinetics·Satoshi S Nishizuka, Gordon B Mills
Dec 2, 2015·Journal of Proteome Research·Kohei KumeSatoshi S Nishizuka
Jan 12, 2008·Current Opinion in Biotechnology·Satoshi Nishizuka, Brett Spurrier
Aug 22, 2007·Proteomics·Brett SpurrierSatoshi Nishizuka
Oct 1, 2008·Proteomics. Clinical Applications·Niroshan RamachandranJoshua Labaer
Oct 14, 2006·Cancer·Axel SchulenburgPeter Valent
Nov 30, 2006·Current Opinion in Oncology
May 29, 2007·Analytical Chemistry·Zhiwen TangWeihong Tan

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