Profiling cell-free and circulating miRNA: a clinical diagnostic tool for different cancers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Chiranjib Chakraborty, Srijit Das

Abstract

Effective cancer management depends on early diagnosis and treatment. There are several microRNAs (miRNAs) which are used for detection of various cancers. Cell-free and circulating miRNAs originate from plasma, either from blood cells or endothelial cells. Cell-free and circulating miRNAs are very much important in the diagnosis and prognosis of cancer therapy. Admittedly, biological knowledge of extracellular miRNAs is still at its preliminary level. Recent discoveries of novel cell-free and circulating miRNAs from the body fluids are now being considered as important biomarkers that may help us in the early diagnosis of any cancer. In the present review, we highlight the biogenesis of miRNAs and their current extracellular pattern, the discovery of circulating miRNA, significant advantages, and different profiling techniques. Finally, we discuss the different circulating miRNAs such as miR-21, miR-20a, miR-155, miR‑221, miR-210, miR-218, miR-200-family, miR-141, miR-122, miR-486-5p, miR‑423-5p, miR-29a, and miR-500 for clinical diagnosis of various cancers. The present review may be beneficial for future researches concerned with miRNAs which are used for detection of various cancers.

References

Apr 24, 2004·Genes & Development·Javier Martinez, Thomas Tuschl
Sep 17, 2004·The EMBO Journal·Yoontae LeeV Narry Kim
Nov 9, 2004·Nature·Ahmet M DenliGregory J Hannon
Dec 3, 2004·Genes & Development·Jinju HanV Narry Kim
Nov 30, 2005·Nucleic Acids Research·Caifu ChenKarl J Guegler
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ligang WuJoel G Belasco
Apr 25, 2006·Molecular Biotechnology·Han-Jiang FuXiao-Fei Zheng
Nov 14, 2006·Nature Structural & Molecular Biology·Glen M BorchertBeverly L Davidson
Jan 27, 2007·The EMBO Journal·Young-Kook Kim, V Narry Kim
Jan 1, 2008·Nature Methods·Stephan C Schuster
Jan 26, 2008·Clinical Chemistry·Stephen S C ChimY M Dennis Lo
Jan 31, 2008·JAMA : the Journal of the American Medical Association·Aaron J SchetterCurtis C Harris
Mar 26, 2008·Nature Biotechnology·Nitzan RosenfeldIris Barshack
Jul 19, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Simona RossiGeorge A Calin
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Jan 24, 2009·Nature Reviews. Molecular Cell Biology·V Narry KimMikiko C Siomi
Feb 17, 2009·TheScientificWorldJournal·Thian-Sze WongWilliam Ignace Wei
Feb 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kai WangDavid J Galas
Mar 18, 2009·Clinical Lung Cancer·Guilherme RabinowitsGoetz H Kloecker
May 21, 2009·BMC Research Notes·Weizhu ZhuEdward R Sauter
Jul 15, 2009·PloS One·Michael J LodesBrooke Anderson
Aug 27, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Noh Jin ParkDavid T Wong
Oct 30, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Yusuke YamamotoTakahiro Ochiya
Oct 31, 2009·International Journal of Cancer. Journal International Du Cancer·Zhaohui HuangXiang Du
Dec 10, 2009·Science Signaling·Alma ZerneckeChristian Weber
Feb 6, 2010·Annals of Surgery·Helen M HeneghanMichael J Kerin
Feb 12, 2010·Methods : a Companion to Methods in Enzymology·Evan M KrohMuneesh Tewari
Mar 12, 2010·Technology in Cancer Research & Treatment·Jana FerdinGeorge A Calin
Mar 17, 2010·Silence·Nobuyoshi KosakaTakahiro Ochiya
Mar 18, 2010·British Journal of Cancer·M TsujiuraE Otsuji
Apr 3, 2010·Translational Oncology·Allen S HoAlbert C Koong
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Jan C BraseHolger Sültmann

❮ Previous
Next ❯

Citations

Jul 4, 2016·Bulletin du cancer·Marc-Antoine BenderraChristophe Massard
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·G OcchipintiF Piva
Oct 25, 2016·Biological Psychiatry·Angélica Torres-BerríoCecilia Flores
Sep 7, 2016·International Journal of Molecular Sciences·Tsutomu KawaguchiEigo Otsuji
Dec 23, 2017·Inflammatory Bowel Diseases·Uri NetzSusan Galandiuk
Dec 3, 2017·Scientific Reports·Haifeng DingWenliang Zhu
Oct 5, 2017·Future Oncology·Veronika HolubekovaZora Lasabova
Sep 17, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Tao ZhuShihua Wang
Nov 21, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Santiago CuestaCecilia Flores
May 8, 2020·Cell Biology International·Chiranjib ChakrabortyGovindasamy Agoramoorthy
Nov 15, 2017·Expert Review of Molecular Diagnostics·Lidia Maria Rebolho Batista ArantesAndré Lopes Carvalho
Dec 11, 2017·Biochemistry. Biokhimii︠a︡·I A KorolevaA N Kucher
Dec 22, 2019·Cells·Óscar Rapado-GonzálezMaría Mercedes Suárez-Cunqueiro
Mar 1, 2020·Molecular Diagnosis & Therapy·Marc HirschfeldThalia Erbes
Jul 2, 2017·Cancer Metastasis Reviews·Preeti Kanikarla-MarieScott Kopetz
Dec 8, 2017·BioMed Research International·Fei WangXiaoping Chen
May 30, 2020·International Journal of Molecular Sciences·Lea DenzerChristian Schwerk
Oct 28, 2020·Technology in Cancer Research & Treatment·Eda G Ramirez-VallesCarlos A Alba-Fierro
Mar 14, 2020·American Journal of Obstetrics and Gynecology·Sarah MoustafaHugh S Taylor
May 27, 2021·Chemical Communications : Chem Comm·Ping ZhouBo Tang
Apr 26, 2017·Endocrinología, Diabetes Y Nutrición·Sandra Rodríguez-RoderoEdelmiro Menéndez Torre

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.