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Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks

Proceedings of the National Academy of Sciences of the United States of America

Jun 15, 2016

Chunshui ZhouS J Elledge

Abstract

The DNA damage response (DDR) is regulated by a protein kinase signaling cascade that orchestrates DNA repair and other processes. Identifying the substrate effectors of these kinases is critical for understanding the underlying physiology and mechanism of the response. We have used qua...read more

Mentioned in this Paper

Saccharomyces cerevisiae Proteins
Phospho1
CHEK2 wt Allele
Establishment and Maintenance of Localization
RFX1 gene
RFX1
DNA Damage Induced Protein Phosphorylation
ESC1
Inositol Phosphates
Flow Cytometry
1
65
Paper Details
References
  • References43
  • Citations9
12345
  • References43
  • Citations9
1

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Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks

Proceedings of the National Academy of Sciences of the United States of America

Jun 15, 2016

Chunshui ZhouS J Elledge

PMID: 27298372

DOI: 10.1073/pnas.1602827113

Abstract

The DNA damage response (DDR) is regulated by a protein kinase signaling cascade that orchestrates DNA repair and other processes. Identifying the substrate effectors of these kinases is critical for understanding the underlying physiology and mechanism of the response. We have used qua...read more

Mentioned in this Paper

Saccharomyces cerevisiae Proteins
Phospho1
CHEK2 wt Allele
Establishment and Maintenance of Localization
RFX1 gene
RFX1
DNA Damage Induced Protein Phosphorylation
ESC1
Inositol Phosphates
Flow Cytometry
1
65

Feeds With Similar Papers

Signal Transduction & Control of Gene Expression

Expression of genes are thought to be involved in signaling pathways, which are important for cell growth, metabolism, apoptosis and more. It is thought that gene expression plays a part in the signaling pathways that implicates the biological effects of the cell. Here is the latest research on signal transduction and the control of gene expression.

Phosphoinositides & Cell Regulation

Phosphoinositides are a subset of membrane phospholipids with wide-ranging effects in cell function.

Related Papers

The Journal of Biological Chemistry

A proteome-wide analysis of kinase-substrate network in the DNA damage response

The Journal of Biological ChemistryMarch 2, 2010
Sheng-hong ChenHuilin Zhou
Molecular and Cellular Biology

Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling

Molecular and Cellular BiologyAugust 15, 2003
Soo-Jung LeeDavid F Stern
Paper Details
References
  • References43
  • Citations9
12345
  • References43
  • Citations9
1

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