Profiling expression changes caused by a segmental aneuploid in maize

BMC Genomics
Irina MakarevitchNathan M Springer

Abstract

While changes in chromosome number that result in aneuploidy are associated with phenotypic consequences such as Down syndrome and cancer, the molecular causes of specific phenotypes and genome-wide expression changes that occur in aneuploids are still being elucidated. We employed a segmental aneuploid condition in maize to study phenotypic and gene expression changes associated with aneuploidy. Maize plants that are trisomic for 90% of the short arm of chromosome 5 and monosomic for a small distal portion of the short arm of chromosome 6 exhibited a phenotypic syndrome that includes reduced stature, tassel morphology changes and the presence of knots on the leaves. The knotted-like homeobox gene knox10, which is located on the short arm of chromosome 5, was shown to be ectopically expressed in developing leaves of the aneuploid plants. Expression profiling revealed that approximately 40% of the expressed genes in the trisomic region exhibited the expected 1.5 fold increased transcript levels while the remaining 60% of genes did not show altered expression even with increased gene dosage. We found that the majority of genes with altered expression levels were located within the chromosomal regions affected by the segmental ane...Continue Reading

References

Sep 1, 1992·Developmental Biology·M Freeling
Oct 1, 1993·Journal of Neurochemistry·M J Fann, P H Patterson
Apr 1, 1996·Genetics·M GuoJ A Birchler
Feb 13, 2001·Current Opinion in Plant Biology·M ByrneR Martienssen
Mar 13, 2001·Plant Physiology·R G KynastR L Phillips
Mar 1, 2003·Nature Reviews. Genetics·Miltos Tsiantis, Angela Hay
May 2, 2003·Nature·Rex Dalton
May 29, 2003·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Maarten KoornneefHans de Jong
Aug 13, 2003·Human Molecular Genetics·Nidhi G SaranRoger H Reeves
Jun 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ralf G KynastRonald L Phillips
Jul 3, 2004·Genome Research·Robert LyleStylianos E Antonarakis
Nov 19, 2004·Nature·Harith Rajagopalan, Christoph Lengauer
Aug 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yan FuPatrick S Schnable
Oct 19, 2006·Current Opinion in Cell Biology·Beth A A Weaver, Don W Cleveland
Feb 13, 2007·The Plant Cell·James A Birchler, Reiner A Veitia
Aug 19, 2007·American Journal of Human Genetics·E Aït Yahya-GraisonM-C Potier

❮ Previous
Next ❯

Citations

Mar 23, 2011·Inflammatory Bowel Diseases·Joel R Pekow, John H Kwon
Nov 26, 2009·Journal of Plant Research·Fang Wei, Gai-Sheng Zhang
Apr 12, 2012·Immunology and Cell Biology·Samuel Forster
Mar 22, 2012·Nucleic Acids Research·Lina E LundbergJan Larsson
Jun 16, 2009·Current Opinion in Rheumatology·Kelvin P JordanUNKNOWN Arthritis Research Campaign National Primary Care Centre
May 7, 2011·BMC Systems Biology·Michaël Bekaert, Gavin C Conant
Sep 2, 2010·Genome Biology·Matthias PrestelPeter B Becker
Feb 27, 2010·PLoS Biology·Xinxian Deng, Christine M Disteche
Jun 17, 2010·PloS One·Anatoliy KravetsElena Rustchenko
Sep 30, 2010·Genetics·Isabelle M HenryLuca Comai
Sep 12, 2014·Plant Molecular Biology·Feng LinHan Zhao
Dec 1, 2015·Trends in Plant Science·Annika K WeimerDaniël Van Damme
Aug 1, 2015·Scientific Reports·Waranya NatesuntornSatoshi Harashima
Sep 13, 2012·Molecular Systems Biology·Silvia StingeleZuzana Storchova
Feb 10, 2010·The Biochemical Journal·James A Birchler
Apr 22, 2015·BMC Developmental Biology·Katerina LochovskaMaria Hovorakova

❮ Previous
Next ❯

Datasets Mentioned

BETA
AI783234
AY107007

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

GCOS
Primer
Affymetrix
Excel
GeneSpring

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.