Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis

British Journal of Cancer
J P Dean, P S Nelson

Abstract

Experimental evidence suggests that ageing-associated alterations in the tissue microenvironment act to promote prostate carcinogenesis. In this review, we survey the cellular state of senescence, review its causes, and describe associations with ageing and cancer. We further discuss senescent stromal gene expression changes, which may mediate these effects, and that may serve as therapeutic targets.

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Citations

Oct 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Massimo AmmiranteMichael Karin
Sep 7, 2013·Molecular Cancer Research : MCR·Holly E BarkerJanine T Erler
Jan 23, 2016·Journal of Proteome Research·Kenneth Robert DurbinNeil L Kelleher
Jun 19, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anita R IskandarJulia Hoeng
Aug 15, 2009·Integrative Cancer Therapies·Katya Chobotova
Sep 14, 2011·Pathology Oncology Research : POR·Wagner José FávaroValéria Helena A Cagnon
Mar 2, 2010·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Amanda C HetzlValéria H A Cagnon
Feb 26, 2009·Médecine sciences : M/S·Oliver BischofPascal Pineau
Nov 22, 2011·Cancer Metastasis Reviews·Paolo Cirri, Paola Chiarugi
Dec 2, 2009·Seminars in Cell & Developmental Biology·Sajni JossonRuoxiang Wang

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Methods Mentioned

BETA
xenograft

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