Profiling of ABC transporters ABCB5, ABCF2 and nestin-positive stem cells in nevi, in situ and invasive melanoma

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Namrata SetiaMeera Mahalingam

Abstract

Distinct ABCB5 forms and ABCF2, members of the ATP-binding cassette (ABC) superfamily of transporters, are normally expressed in various tissues and cells, and enhanced expression of both has been demonstrated in select cancers. In melanoma cell lines, gene expression profiling of ABC transporters has revealed enhanced expression of melanocyte-specific ABCB5 and ABCF2 proteins. Given this, our primary aim was to ascertain immunohistochemical expression of the ABC transporters ABCB5 and ABCF2 and, the stem cell marker, nestin in a spectrum of benign and malignant nevomelanocytic proliferations, including nevi (n=30), in situ (n=31) and invasive (n=24) primary cutaneous melanomas to assess their role in the stepwise development of malignancy. In addition, their expression was compared with established melanoma prognosticators to ascertain their utility as independent prognosticators. A semiquantitative scoring system was utilized by deriving a cumulative score (based on percentage positivity cells and intensity of expression) and statistical analyses was carried out using analysis of variance with linear contrasts. Mean cumulative score in nevi, in situ and invasive melanoma were as follows: 3.8, 4.4 and 5.3 for ABCB5, respective...Continue Reading

References

Sep 10, 2003·The Journal of Biological Chemistry·Natasha Y FrankMarkus H Frank
Feb 20, 2004·Cancer Research·Kohichiroh YasuiJohji Inazawa
May 19, 2005·Cancer Research·Natasha Y FrankMarkus H Frank
Dec 5, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Walter M KleinSteven R Tahan
Feb 27, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Elena MonzaniCaterina A M La Porta
Apr 24, 2007·Journal of Cutaneous Pathology·Svetlana BrychtovaJaroslav Hirnak
May 9, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Juergen J WenzelWolfgang E Kaminski
Jan 19, 2008·Nature·Tobias SchattonMarkus H Frank
Aug 28, 2009·Expert Opinion on Drug Metabolism & Toxicology·Yi An, Weg M Ongkeko
Jul 20, 2010·The Journal of Surgical Research·Bhuvnesh K SharmaE George Elias
Jun 10, 2011·Cancer Research·Brian J WilsonNatasha Y Frank

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Citations

Sep 14, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rita G LadsteinLars A Akslen
Feb 2, 2016·The Journal of Investigative Dermatology·Sonja KleffelTobias Schatton
Jun 19, 2013·Biochemical and Biophysical Research Communications·Jennifer Y LinMarkus H Frank
Nov 22, 2017·Medical Sciences : Open Access Journal·Ugo TestaElvira Pelosi
Feb 21, 2018·Cancers·Ilaria Roato, Riccardo Ferracini
Oct 16, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Nayoung LeeTobias Schatton
Jul 7, 2020·Molecular Biology Reports·Mehmet Bugrahan Duz, Omer Faruk Karatas

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