Profiling of circulating microRNAs for prostate cancer biomarker discovery

Drug Delivery and Translational Research
Christa HaldrupKarina D Sorensen

Abstract

Prostate cancer (PC) is the most frequent cancer in men in the Western world. Currently, serum prostate-specific antigen levels and digital rectal examinations are used to indicate the need for diagnostic prostate biopsy, but lack in specificity and sensitivity. Thus, many men undergo unnecessary biopsy, and better and less invasive tools for PC detection are needed. Furthermore, whereas aggressive PC should be treated immediately to prevent dissemination, indolent PC often does not progress and overtreatment should be avoided. Currently, the best predictors of aggressiveness are Gleason score and T-stage of the primary PC. Better tools to assess PC aggressiveness could aid in treatment decisions. Recently, circulating miRNAs have been suggested as potential new biomarkers for PC with diagnostic and prognostic potential. Here, to identify new serum miRNA biomarker candidates for PC, we performed genome-wide miRNA profiling of serum samples from 13 benign prostatic hyperplasia (BPH) control patients and 31 PC patients. Furthermore, we carefully reviewed the literature on circulating miRNA biomarkers for PC. Our results confirmed the de-regulation of miR-141 and miR-375, two of the most well-documented candidate miRNA markers for...Continue Reading

References

Aug 3, 2002·Nature Reviews. Immunology·Clotilde ThérySebastian Amigorena
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Jan 16, 2009·Trends in Cell Biology·Emanuele CocucciJacopo Meldolesi
May 16, 2009·Current Opinion in Cell Biology·Mikael Simons, Graça Raposo
Jul 15, 2009·PloS One·Michael J LodesBrooke Anderson
Nov 26, 2009·The American Journal of Surgical Pathology·Tineke WoltersGeert J L H van Leenders
Feb 2, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayE Steliarova-Foucher
May 5, 2010·Nature Reviews. Clinical Oncology·Peter C Albertsen
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Jan C BraseHolger Sültmann
Jun 29, 2010·Cancer Cell·Barry S TaylorWilliam L Gerald
Jan 29, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fulya Yaman AgaogluUgur Gezer
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jason D ArroyoMuneesh Tewari
May 26, 2011·Nucleic Acids Research·Andrey TurchinovichBarbara Burwinkel
Nov 5, 2011·International Journal of Cancer. Journal International Du Cancer·Luke A SelthLisa M Butler
Jan 14, 2012·British Journal of Cancer·R J BryantF C Hamdy
Jan 21, 2012·Trends in Cell Biology·Xi ChenChen-Yu Zhang
Feb 10, 2012·Expert Review of Anticancer Therapy·Li ZhouHong Shu
Apr 12, 2012·Endocrine-related Cancer·Luke A SelthLisa M Butler
May 2, 2012·Journal of Experimental & Clinical Cancer Research : CR·Ruimin MaXixiong Kang
May 23, 2012·BJU International·Brian D KellyMichael J Kerin
May 24, 2012·International Journal of Cancer. Journal International Du Cancer·N A HealyM J Kerin
Sep 1, 2012·Current Urology Reports·Alexander P GlaserBrian T Helfand

❮ Previous
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Citations

Feb 9, 2016·Diagnostics·Virginie Vlaeminck-Guillem
Sep 22, 2015·Journal of Clinical Medicine·Wei-Ting KuoWen-Chang Lin
Jan 26, 2016·European Urology·Linda FabrisGeorge A Calin
Jan 20, 2016·Pediatric Obesity·M L MansegoUNKNOWN GENOI members
Jan 12, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Xavier Filella, Laura Foj
Mar 25, 2016·International Journal of Molecular Sciences·Gloria BertoliIsabella Castiglioni
Jul 8, 2016·Journal of Human Genetics·Takashi KinoshitaFei-Fei Liu
Nov 3, 2016·Nature Reviews. Urology·Annika FendlerKlaus Jung
Dec 23, 2015·International Journal of Molecular Sciences·Jing-Wen ShihChia-Ling Hsieh
May 9, 2018·Angiogenesis·Anna Janaszak-JasieckaRafal Bartoszewski
Dec 21, 2017·BioMed Research International·Jin YanGuoxin Zhang
Jun 23, 2018·Experimental Biology and Medicine·Ahmed A MoustafaAsim B Abdel-Mageed
Sep 8, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Cintia MassilloAdriana De Siervi
Sep 9, 2017·PloS One·David J SchultzCarolyn M Klinge
Mar 22, 2019·International Journal of Molecular Sciences·Emma Scott, Jennifer Munkley
Feb 28, 2020·Medicina·Vlad Cristian MunteanuIoan Coman
Apr 9, 2020·Epigenomics·Irena AbramovicNino Sincic
Dec 17, 2017·Oncotarget·Bo ZhengQiang Xia
Jan 17, 2017·Bulletin of Experimental Biology and Medicine·A I Osip'yantsB Ya Alekseev
Jul 18, 2018·International Urology and Nephrology·Paweł PorzyckiMirosław Tyrka
Dec 15, 2018·Journal of Cellular and Molecular Medicine·Maria Assunta PianoMaria Luisa Calabrò
Sep 10, 2019·Expert Review of Molecular Diagnostics·Philip ZeuschnerKerstin Junker
Jul 17, 2020·Cancer Management and Research·Christopher J McNallyDeclan J McKenna
Mar 23, 2017·BMC Urology·Hung N LuuGiuliano Di Pietro
Aug 14, 2020·International Journal of Molecular Sciences·Ewa CiszkowiczMirosław Tyrka
Feb 28, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fumihiko UrabeTakahiro Ochiya
Feb 25, 2021·Journal of Experimental & Clinical Cancer Research : CR·Simona GiglioAndrea Vecchione
Jun 25, 2018·Translational Research : the Journal of Laboratory and Clinical Medicine·Irbaz Bin RiazManish Kohli

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