Abstract
To reveal the clinical significance of criteria and non-criteria antiphospholipid antibodies detected by line immunoassay in comparison with ELISA, systemic lupus erythematosus patients with and without thrombotic events were investigated. Thus, 107 systemic lupus erythematosus patients (48% with deep vein thrombosis or/and arterial thrombosis) and 120 healthy donors were enrolled. Serum antiphospholipid antibodies were detected by ELISA (Orgentec Diagnostika, Germany) and line immunoassay (GA Generic Assays, Germany). Lupus anticoagulant and IgG to cardiolipin and β2GPI but not IgM as well as triple positivity by ELISA and line immunoassay were linked with thrombosis in systemic lupus erythematosus. IgG to phosphatidylinositol and phosphatidylserine by line immunoassay showed significantly higher levels in systemic lupus erythematosus with deep vein thrombosis/arterial thrombosis than without and were independent risk factors for deep vein thrombosis (odds ratio 3.9, 95% confidence interval 1.1, 13.2) and arterial thrombosis (odds ratio 5.1, 95% confidence interval 1.3, 19.8) as well as thrombosis (odds ratio 3.6, 95% confidence interval 1.1, 11.3) and recurrence thereof (odds ratio 6.9, 95% confidence interval 2.1, 22.6), res...Continue Reading
References
Aug 1, 1990·American Journal of Obstetrics and Gynecology·N S RoteD W Branch
Feb 1, 1997·Rheumatic Diseases Clinics of North America·L ZiporenY Shoenfeld
Oct 24, 2002·Blood·Monica GalliTiziano Barbui
Apr 16, 2003·Annals of the Rheumatic Diseases·R A Asherson, R Cervera
Apr 30, 2003·Arthritis Research & Therapy·Khanh T Ho, John D Reveille
Jul 20, 2004·Angiology·Panagiota BouraJannis Kountouras
Jun 22, 2005·Thrombosis and Haemostasis·Vittorio PengoSabino Iliceto
Jan 20, 2006·Journal of Thrombosis and Haemostasis : JTH·S MiyakisS A Krilis
Oct 9, 2009·Autoimmunity·Angela TincaniPier Luigi Meroni
May 11, 2011·Nature Reviews. Rheumatology·Pier Luigi MeroniFrancesco Tedesco
Jul 23, 2011·Arthritis Research & Therapy·Karl EgererThomas Dörner
May 4, 2012·Arthritis and Rheumatism·Michelle PetriLaurence S Magder
May 24, 2012·Seminars in Thrombosis and Hemostasis·Philip G de Groot, Rolf T Urbanus
Sep 26, 2012·Autoimmunity Reviews·Dirk RoggenbuckThomas Dörner
Dec 12, 2012·Autoimmunity Reviews·V PengoA Ruffatti
Jan 15, 2014·Autoimmunity Reviews·Quitterie ReynaudSilvy Laporte
Jan 28, 2014·Journal of Autoimmunity·Jose A Gómez-Puerta, Ricard Cervera
Feb 7, 2014·Seminars in Thrombosis and Hemostasis·Gary W Moore
Apr 23, 2014·International Journal of Laboratory Hematology·K M J Devreese
Sep 18, 2014·Lupus·D RoggenbuckP L Meroni
Apr 16, 2015·Journal of Immunology Research·Roberta MisasiMaurizio Sorice
May 23, 2016·Arthritis Research & Therapy·Dirk RoggenbuckPier Luigi Meroni
Jun 10, 2016·Journal of Thrombosis and Haemostasis : JTH·H KelchtermansK M Devreese
Aug 9, 2017·Frontiers in Endocrinology·Mathilde Versini
May 31, 2018·Auto- Immunity Highlights·Cecilia NalliAngela Tincani
Jun 10, 2018·Autoimmunity Reviews·Cristina BeliznaKatrien Devreese
May 17, 2019·Annals of the Rheumatic Diseases·Maria G TektonidouMichael M Ward