Profiling of volatile organic compounds produced by clinical Aspergillus isolates using gas chromatography-mass spectrometry

Medical Mycology
M G GerritsenP J Sterk

Abstract

Volatile organic compounds (VOCs) in exhaled breath may identify the presence of invasive pulmonary aspergillosis. We aimed to detect VOC profiles emitted by in vitro cultured, clinical Aspergillus isolates using gas chromatography-mass spectrometry (GC-MS). Three clinical Aspergillus isolates and a reference strain were cultured while conidiation was prevented. Headspace samples were analyzed using a standardized method. Breath samples of patients from which the cultures were obtained were checked for the presence of the VOCs found in vitro. Each Aspergillus isolate produced a distinct VOC profile. These profiles could not be confirmed in exhaled breath in vivo.

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Citations

Mar 7, 2020·Journal of Clinical Microbiology·David Terrero-Salcedo, Margaret V Powers-Fletcher
Apr 8, 2021·Metabolomics : Official Journal of the Metabolomic Society·Andrea Rios-NavarroAdriana Marcela Celis Ramírez
Sep 6, 2017·ACS Infectious Diseases·Waqar M AhmedStephen J Fowler
Jul 2, 2020·The Science of the Total Environment·Carmen KalalianChristian George

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Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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