Profiling proteins related to amyloid deposited brain of Tg2576 mice

Proteomics
Su Jeon ShinInhee Mook-Jung

Abstract

Alzheimer's disease (AD) is an age-related neurodegenerative disorder that is characterized by the extracellular deposition of beta-amyloid and intracellular hyperphosphorylation of tau in the cortex and hippocampus of the brain. These characterizations are caused by abnormal expression, modification and deposition of certain proteins. Post-translational modifications of proteins including oxidation and nitration might be involved in the pathogenesis of AD. In this study, AD-related proteins were identified in the cortex of Tg2576 mice used as a model for studying AD. Tg2576 mice express high levels of the Swedish mutated form of human beta-amyloid precursor protein (APP) and generated high levels of beta-amyloid in the brains. Using Western blotting and two-dimensional electrophoresis, proteins with differences in expression, oxidation and nitration in the cortex of Tg2576 mice brains were compared to littermate mice brains used as a control. The proteins with different expression levels were identified using matrix-assisted laser desorption/ionization-time of flight and liquid chromatography-tandem mass spectrometry analyses. As a result, 12 proteins were identified among 37 different proteins using the PDQuest program. Furth...Continue Reading

References

Mar 1, 1997·The International Journal of Biochemistry & Cell Biology·S K Powell, H K Kleinman
Jul 1, 1997·Neurobiology of Aging·W R Markesbery
May 10, 2000·The Journal of Biological Chemistry·A CapellC Haass
Jul 14, 2000·Annals of Neurology·S D GinsbergJ Q Trojanowski
Sep 16, 2000·Biochemical Society Symposium·S J Tabrizi, A H Schapira
Feb 24, 2001·Annals of the New York Academy of Sciences·P H St George-Hyslop
Feb 24, 2001·Annals of the New York Academy of Sciences·J Poirier
Dec 6, 2001·Trends in Molecular Medicine·D A ButterfieldA Castegna
Jan 15, 2002·DNA and Cell Biology·J F LoringR Somogyi
Feb 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Clive Holmes
Nov 21, 2002·Proteomics·Michael FountoulakisGert Lubec
Dec 5, 2002·Neurochemical Research·Elliott J MufsonStephen D Ginsberg
Feb 13, 2003·Journal of Neuropathology and Experimental Neurology·Magdalena O ZemaitaitisNancy A Muma
Apr 5, 2003·Biological Chemistry·Steve SimoneauCorinne Lasmézas
Jun 6, 2003·Journal of Neurochemistry·Alessandra CastegnaD Allan Butterfield
Sep 3, 2003·Journal of Neurochemistry·D Allan ButterfieldAlessandra Castegna

❮ Previous
Next ❯

Citations

Jul 15, 2009·Acta Neuropathologica·Ester Perez-GraciaIsidro Ferrer
Nov 23, 2006·Antioxidants & Redox Signaling·Orly WeinrebMoussa B H Youdim
Aug 5, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Mark D JohnsonRichard S Morrison
Jan 15, 2011·International Journal of Alzheimer's Disease·Issam El GhaziIan M Armitage
Jul 27, 2010·Expert Review of Proteomics·Carlo RodolfoGian Maria Fimia
Aug 5, 2010·Experimental Neurology·James W Geddes, Kathryn E Saatman
May 5, 2009·Biochimica Et Biophysica Acta·Francesca MagheriniAlessandra Modesti
Aug 16, 2008·Ageing Research Reviews·Renã A SowellD Allan Butterfield
Sep 2, 2008·Neurobiology of Aging·David F FischerFred W van Leeuwen
Mar 24, 2006·Electrophoresis·Michael Fountoulakis, Sophia Kossida
May 1, 2008·Proteomics. Clinical Applications·Nicolas BousetteThomas Kislinger
Nov 13, 2008·Journal of Cellular Biochemistry·Jacqueline VazquezMary Ann Greco
Mar 19, 2016·European Journal of Pharmacology·Kenji MatsuuraShogo Matsuyama
Nov 30, 2006·Journal of Neuroscience Research·Radhika A VaishnavThomas V Getchell
Sep 26, 2006·Drug Discovery Today·Maria E SaezAgustin Ruiz
Jul 16, 2005·Biochemical and Biophysical Research Communications·Jennifer L MarcumRodney P Guttmann
Jan 30, 2015·Biological Reviews of the Cambridge Philosophical Society·Vincent DiGiacomo, Daniel Meruelo
May 14, 2011·Free Radical Biology & Medicine·Rodney P Guttmann, Sarbani Ghoshal
Apr 1, 2010·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Imran AliBhavtosh Sharma
May 29, 2012·Neurochemistry International·Masaoki TakanoShogo Matsuyama
Feb 10, 2010·Journal of Psychopharmacology·Regina TaurinesJohannes Thome
Dec 15, 2015·Molecular & Cellular Proteomics : MCP·Guillermo Moya-AlvaradoFrancisca C Bronfman
Oct 12, 2018·American Journal of Physiology. Renal Physiology·Sorena LoNirmala Parajuli
Mar 2, 2011·Physiology·Paul H AxelsenIan V J Murray
Nov 28, 2018·JAD Reports·Aise Rumeysa MaziAhmet Tarik Baykal

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