Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)

PloS One
Yana YunusovaJordan R Green

Abstract

This study examines reading aloud in patients with amyotrophic lateral sclerosis (ALS) and those with frontotemporal dementia (FTD) in order to determine whether differences in patterns of speaking and pausing exist between patients with primary motor vs. primary cognitive-linguistic deficits, and in contrast to healthy controls. 136 participants were included in the study: 33 controls, 85 patients with ALS, and 18 patients with either the behavioural variant of FTD (FTD-BV) or progressive nonfluent aphasia (FTD-PNFA). Participants with ALS were further divided into 4 non-overlapping subgroups--mild, respiratory, bulbar (with oral-motor deficit) and bulbar-respiratory--based on the presence and severity of motor bulbar or respiratory signs. All participants read a passage aloud. Custom-made software was used to perform speech and pause analyses, and this provided measures of speaking and articulatory rates, duration of speech, and number and duration of pauses. These measures were statistically compared in different subgroups of patients. The results revealed clear differences between patient groups and healthy controls on the passage reading task. A speech-based motor function measure (i.e., articulatory rate) was able to dist...Continue Reading

References

Jan 1, 1979·Phonetica·F Grosjean, M Collins
Dec 1, 1992·Journal of Speech and Hearing Research·E E Sperry, R J Klich
Jun 1, 1983·Journal of Speech and Hearing Research·R D Kent, J C Rosenbek
Mar 1, 1980·Journal of Psycholinguistic Research·E J Clemmer
Dec 1, 1993·Journal of Speech and Hearing Research·G S Turner, G Weismer
May 1, 1993·The American Review of Respiratory Disease·L LeeR Stuebing
Feb 1, 1996·Journal of Speech and Hearing Research·H L MitchellP J Watson
Nov 1, 1996·Journal of Communication Disorders·V L Hammen, K M Yorkston
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B R BrooksUNKNOWN World Federation of Neurology Research Group on Motor Neuron Diseases
Apr 8, 2004·Brain and Language·Thomas H Bak, John R Hodges
May 26, 2005·Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP)·Yu-Tsai WangJack E Thomas
Jul 29, 2006·Behavioural Neurology·Serena AmiciBruce L Miller
Dec 11, 2007·Neuropsychologia·S WarkentinS Janciauskiene
Dec 20, 2007·Alzheimer Disease and Associated Disorders·Jennifer M OgarMaria Luisa Gorno-Tempini
Apr 3, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Sabine Skodda, Uwe Schlegel
Sep 16, 2008·Respiratory Physiology & Neurobiology·Jessica E Huber
May 12, 2009·Neuropsychologia·S M BrambatiM L Gorno-Tempini
May 23, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Michael J StrongDenise Figlewicz
Aug 22, 2009·Brain : a Journal of Neurology·Jonathan A KnibbKaralyn Patterson
Jan 27, 2010·Clinical Linguistics & Phonetics·Kristin RosenLouise Corben
Jun 15, 2010·Brain : a Journal of Neurology·Stephen M WilsonMaria Luisa Gorno-Tempini
Jul 1, 2010·Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP)·Yu-Tsai WangJane Finley Kent
Sep 11, 2010·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Serguei V S PakhomovDavid S Knopman
Sep 17, 2010·Journal of Speech, Language, and Hearing Research : JSLHR·Jessica E Huber, Meghan Darling
Feb 18, 2011·Neurology·M L Gorno-TempiniM Grossman
Apr 14, 2011·Journal of the International Neuropsychological Society : JINS·Ralph H B BenedictBianca Weinstock-Guttman
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
Jul 1, 2009·Journal of Neurolinguistics·Sharon AshMurray Grossman
Jan 5, 2012·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Patricia LilloJohn R Hodges
Aug 1, 2012·American Journal of Speech-language Pathology·Jessica E HuberDabao Zhang
Sep 25, 2012·Neuropsychologia·Anna M Woollams, Karalyn Patterson
Oct 13, 2012·Journal of the International Neuropsychological Society : JINS·Jonathan D RodgersRalph H B Benedict
Aug 1, 2013·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Jordan R GreenJames D Berry
Oct 18, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Marianna AmboniJeffrey M Hausdorff
Mar 1, 1973·Journal of Psycholinguistic Research·S R Rochester
Nov 16, 2013·Seminars in Neurology·Youngsin JungKeith A Josephs
Nov 19, 2013·Journal of the Neurological Sciences·Richard A OsborneSanjay Kalra

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Citations

Mar 31, 2017·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Kristen M AllisonJordan R Green
Jan 16, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Joanna CzarzastaJoanna Wojtkiewicz
Mar 27, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R A SmithE P Pioro
Sep 27, 2018·International Journal of Speech-language Pathology·Panying RongJordan R Green
Nov 21, 2018·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
Mar 16, 2017·Journal of Speech, Language, and Hearing Research : JSLHR·Matthew L PooleAdam P Vogel
Nov 22, 2017·International Journal of Language & Communication Disorders·Tanja MakkonenJohanna Palmio
Mar 7, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Carolina BarnettYana Yunusova
Nov 7, 2019·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Panying RongJordan R Green
Jun 24, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Madeline KellyKevin Talbot
Jul 11, 2020·American Journal of Alzheimer's Disease and Other Dementias·Rachel A SluisAnthony J Angwin
Jul 11, 2020·The Journal of Craniofacial Surgery·Dina Levy-LambertEduardo D Rodriguez
Dec 14, 2018·Frontiers in Neurology·Foteini ChristidiPeter Bede
Mar 7, 2019·Frontiers in Neurology·Yana YunusovaPeter Bede
May 30, 2019·Annals of Clinical and Translational Neurology·James D BerryJukka Pekka Onnela
Jan 3, 2019·The Journal of the Acoustical Society of America·Rene L UtianskiKeith A Josephs
Jul 29, 2018·American Journal of Speech-language Pathology·Lynda FeenaughtyRalph H B Benedict
Nov 26, 2019·Logopedics, Phoniatrics, Vocology·Rita Chiaramonte, Marco Bonfiglio
Nov 17, 2020·Journal of the International Neuropsychological Society : JINS·Lynda FeenaughtyKris Tjaden
Dec 9, 2020·American Journal of Speech-language Pathology·Ashley A WaitoYana Yunusova
Feb 4, 2021·CoDAS·Lavoisier Leite NetoRegina Yu Shon Chun
Feb 26, 2021·American Journal of Speech-language Pathology·Panying Rong, Lindsey Heidrick
Jun 16, 2021·Artificial Intelligence in Medicine·Alexandra-Maria TăuţanEmiliano Santarnecchi
Jul 6, 2021·Frontiers in Neurology·Kaila L StipancicJordan R Green
Nov 18, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration

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Software Mentioned

Adobe Audition
SPSS Statistics
MATLAB
SPA
SPSS
Speech Pause Analysis ( SPA )

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