PMID: 6987510Jan 1, 1980Paper

Proflavin: an unusual mutagen

Mutation Research
W T Speck, H S Rosenkranz

Abstract

In the Salmonella typhimurium mutagenicity assay, proflavin (PF), in the dark, was shown to possess some direct-acting frameshift mutagenic activity for strains TA1537 and TA98. In the presence of microsomal enzymes from mouse, hamster and rat livers, frameshift mutagenic activity for strain TA1538 and enhanced mutagenicity for strain TA1537 was observed. Exposure of bacteria to PF in the presence of visible light resulted in base substitution (strain TA1535) as well as frameshift (TA1537, TA1538, TA98) genetic activities. The findings are taken to indicate that PF possesses direct-acting frameshift activity (TA1537 and TA98) by virtue of its ability to intercalate between DNA base-pairs. The frameshift activity (TA1538, TA98 and enhanced TA1537) seen following metabolic or photo-activation may be due to the formation of chemical adducts between the cellular DNA and oxidation products of PF (a base-displacement effect). The light-induced base-substitution activity probably results from the generation of singlet oxygen which reacts with the guanine moiety of DNA. The mutagenic photoproduct of PF appears to be stable.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Nov 6, 1975·The New England Journal of Medicine·M G MyersK A Arndt
Mar 4, 1977·Annals of the New York Academy of Sciences·J L Melnick, C Wallis
Jan 1, 1977·Mutation Research·D S LongneckerD S Daniel
Aug 1, 1977·Mutation Research·B GutterH S Rosenkranz
Apr 1, 1979·Journal of the National Cancer Institute·L A Poirier, F J de Serres
Jan 1, 1979·Mutation Research·W T SpeckH S Rosenkranz
Jul 1, 1978·The Journal of Pediatrics·R M SantellaW T Speck
Mar 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J McCann, B N Ames
Oct 15, 1976·Experimental Cell Research·B GutterB F Erlanger
Mar 18, 1977·Biochimica Et Biophysica Acta·B GutterH S Rosenkranz
Jul 1, 1977·Photochemistry and Photobiology·D L EngelhardtW T Speck
May 1, 1976·Pediatric Research·W T Speck, H S Rosenkranz
Jun 2, 1976·Biochimica Et Biophysica Acta·W T SpeckH S Rosenkranz
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
May 1, 1975·Photochemistry and Photobiology·W T Speck, H S Rosenkranz
Mar 1, 1975·Pediatric Research·W T SpeckH S Rosenkranz
Sep 1, 1975·Pediatric Research·W T Speck, H S Rosenkranz
Mar 1, 1966·Photochemistry and Photobiology·C Wallis, J L Melnick
Aug 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·E TerzaghiA Tsugita
Oct 24, 1966·Biochimica Et Biophysica Acta·K S Sastry, M P Gordon
Dec 30, 1961·Nature·F H CRICKR J WATTS-TOBIN
Dec 1, 1961·Journal of Molecular Biology·A ORGEL, S BRENNER
Nov 1, 1974·Antimicrobial Agents and Chemotherapy·J D LanierJ O Oh
Dec 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·Y OkadaA Tsugita

Citations

Jan 1, 1990·Bioelectromagnetics·M L MeltzD N Erwin
Sep 1, 1988·Mutation Research·B Beije, L Möller
Sep 1, 1981·Mutation Research·P R YoungN R Kallenbach
Sep 1, 1981·Mutation Research·E C McCoyR Mermelstein
Jul 1, 1981·Mutation Research·R MermelsteinH S Rosenkranz
Dec 1, 1985·Environmental Health Perspectives·P J O'Brien
Mar 31, 2018·The Journal of Biological Chemistry·William Douglass WrightWolf-Dietrich Heyer
Oct 24, 2006·Genetics·Leslie BarbourWei Xiao
Jul 17, 1998·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S M PlakasW L Hayton
Jan 1, 1981·Environmental Mutagenesis·E C McCoyR Mermelstein
May 1, 1984·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·N Houba-HérinA Van de Vorst
Oct 6, 2011·Physical Chemistry Chemical Physics : PCCP·Natalia BustoFernando Secco
Jan 7, 2006·Cancer Research·John P WittschiebenRichard D Wood

Related Concepts

Acridines
Genetic Code
Genetic Techniques
Cricetus
Clastogens
Proflavine
Salmonella typhimurium LT2
Transcription, Genetic

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
B N AmesW E Durston
Proceedings of the National Academy of Sciences of the United States of America
J McCannB N Ames
Biochemical and Biophysical Research Communications
H S Rosenkranz, W T Speck
© 2021 Meta ULC. All rights reserved