Jan 1, 1981

Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats

Neurobiology of Aging
R T BartusB Beer

Abstract

In an attempt to gain some insight into possible approaches to reducing age-related memory disturbances, aged Fischer 344 rats were administered either vehicle, choline, piracetam or a combination of choline or piracetam. Animals in each group were tested behaviorally for retention of a one trial passive avoidance task, and biochemically to determine changes in choline and acetylcholine levels in hippocampus, cortex and striatum. Previous research has shown that rats of this strain suffer severe age-related deficits on this passive avoidance task and that memory disturbances are at least partially responsible. Those subjects given only choline (100 mg/kg) did not differ on the behavioral task from control animals administered vehicle. Rats given piracetam (100 mg/kg) performed slightly better than control rats (p less than 0.05), but rats given the piracetam/choline combination (100 mg/kg of each) exhibited retention scores several times better than those given piracetam alone. In a second study, it was shown that twice the dose of piracetam (200 mg/kg) or choline (200 mg/kg) alone, still did not enhance retention nearly as well as when piracetam and choline (100 mg/kg of each) were administered together. Further, repeated admi...Continue Reading

Mentioned in this Paper

Choline
Cortex Bone Disorders
Adrenal Cortex Diseases
Neostriatum
Brain
Senility
Pyrrolidinones
Rats, Inbred F344
Memory Disorders
Genus Hippocampus

About this Paper

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