PMID: 9182870Jan 1, 1997Paper

Profound effects of the weak environmental estrogen-like chemical bisphenol A on the growth of the mammary gland of Noble rats

The Journal of Steroid Biochemistry and Molecular Biology
J B Colerangle, D Roy

Abstract

In the present study we have examined the effects of the environmental estrogenic chemical bisphenol A on proliferative activity, cell cycle kinetics and differentiation of the mammary gland of female Noble rats. Differentiation measured by the degree of lobular maturation revealed that the conversion of immature structures to mature structures was significantly increased in response to exposure to both low (0.1 mg/kg/day) and high (54 mg/kg/day) doses of bisphenol A compared to controls. The proliferative activity of epithelial cells was increased by 143% over controls by the exposure of animals to the low dose of bisphenol A, whereas a 220% increase over controls was observed for the high dose of bisphenol A. The labelling index and growth fraction were 19% and 27%, respectively, for a low dose of bisphenol A; and 27% and 45%, respectively, for a high dose of bisphenol A, compared to 18% and 31%, respectively, in controls. A significant increase in the conversion of mammary epithelial cells from G0, to G1, and S-phase cells by 1.8 and 4.5-fold, respectively, was observed in animals exposed to the high dose of bisphenol A compared to that of controls. Based on the previously reported estrogenic activity of an equivalent dose o...Continue Reading

References

Feb 2, 1978·The New England Journal of Medicine·W J CohnP S Guzelian
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·B HammondJ McConnell
May 1, 1991·Environmental Health Perspectives·A M SotoC Sonnenschein
Jan 1, 1995·Environmental and Molecular Mutagenesis·A Atkinson, D Roy
Apr 20, 1994·Journal of the National Cancer Institute·N KriegerN Orentreich
Apr 21, 1993·Journal of the National Cancer Institute·D J Hunter, K T Kelsey
Apr 21, 1993·Journal of the National Cancer Institute·M S WolffN Dubin
Feb 1, 2006·Clinical and Experimental Pharmacology & Physiology·Xiang-Qin MaShi-Ai Weng

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Citations

Aug 21, 2003·General and Comparative Endocrinology·Shawichi IwamuroSakae Kikuyama
Sep 3, 2002·Research in Veterinary Science·Jeong-Hun Kang, Fusao Kondo
Jun 2, 2000·Chemosphere·M FürhackerH Weber
Jan 5, 2002·Dental Materials : Official Publication of the Academy of Dental Materials·Jane C AtkinsonGordon Jones
Apr 27, 2001·Toxicology Letters·B Heinrich-HirschU Gundert-Remy
Jan 10, 2002·Reproductive Toxicology·M EmaA Harazono
Jul 10, 2003·Reproductive Toxicology·Thomas StrohekerMarie-Chantal Canivenc-Lavier
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·N Ben-Jonathan, R Steinmetz
May 12, 2000·Proceedings of the Society for Experimental Biology and Medicine·D M Sheehan
Jan 12, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Calvin C WillhiteClifton J McLellan
Nov 9, 2001·Journal of Toxicology and Environmental Health. Part a·S D YooK L Park
Apr 9, 2002·Journal of Toxicology and Environmental Health. Part a·Beom Soo ShinKui Lea Park
Oct 30, 2004·Journal of Toxicology and Environmental Health. Part a·Beom Soo ShinSun Dong Yoo
Mar 16, 2012·Endocrine Reviews·Laura N VandenbergJohn Peterson Myers
Feb 18, 2004·The Journal of Reproduction and Development·Satoshi ImanishiHajime Miyamoto
Mar 8, 2000·Environmental Health Perspectives·X LongR M Bigsby
Jun 16, 2000·Environmental Health Perspectives·S H Safe
Jun 13, 2002·Environmental Health Perspectives·Rosa Maria FaccioloFrancesco Dessì-Fulgheri
May 26, 2012·Indian Journal of Endocrinology and Metabolism·Manu RatheeJyotirmay Singh
Nov 22, 2013·Reproductive Toxicology·Joyce Zalotti BrandtWellerson Rodrigo Scarano
Nov 6, 2009·American Journal of Public Health·Sarah A Vogel
Oct 28, 2015·International Journal of Environmental Research and Public Health·Maohua MiaoDe-Kun Li
Nov 3, 2010·Biochimica Et Biophysica Acta·Victor OkohDeodutta Roy
Sep 11, 2007·Reproductive Toxicology·Laura N VandenbergWade V Welshons
Oct 6, 2007·Journal of Environmental Sciences (China)·Da-qiang YinAi-qian Zhang
May 27, 2004·Journal of Biomedical Materials Research. Part a·Homa Darmani, Ahmad S Al-Hiyasat
May 25, 2004·European Journal of Oral Sciences·Ahmad S Al-HiyasatAhmed M Elbetieha
Jan 10, 2004·Journal of Neurochemistry·Takashi YonedaYoshihiko Funae
Feb 21, 2004·Biochemical and Biophysical Research Communications·Yuichi SekineTadashi Matsuda
Oct 18, 2005·Molecular and Cellular Endocrinology·Alzbeta MlynarcíkováSona Scsuková
Oct 1, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mi Eun KimJaewon Lee
Jan 29, 2000·The Journal of the American Dental Association·E Y FungD M Meyer

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