Profound reduction of mature B cell numbers, reactivities and serum Ig levels in mice which simultaneously carry the XID and CD40 deficiency genes

International Immunology
Y OkaF Melchers

Abstract

It has been known for some time that single mutant nude or CD40T mice have apparently normal numbers of cells in the precursor compartments of bone marrow and the mature B cell compartments of the periphery. X-linked immunodeficiency (XID) mice are deficient only in some of the sIgM+sIgD+ B cells. We have investigated further the contributions of the xid mutation, of the T cell deficiency of nude of the inability of CD40T cells to cooperate with T cells in the generation of the precursor and the mature B cell compartments in mice. Double mutant XID/nu and XID/CD40T mice have precursor B cell compartments that are no more deficient than the single mutant XID mice. However, the peripheral B cell compartments of both XID/mu and XID/CD40T are even more deficient than those of single mutant XID mice. While 10% of the peripheral B cells of wild-type or CD40T, one-third of XID and half of XID/nu mice turn over rapidly, as many as three-quarters of those in XID/CD40T are short-lived. Total numbers of sIgM+sIgD+ B cells in the spleen are at best 10-15% of normal mice at 6-8 weeks of age in XID, XID/nu and XID/CD40T mice. They remain that low at 3 months of age in XID/CD40T mice, while in XID mice these peripheral B cells slowly build up...Continue Reading

Citations

Dec 1, 1996·Immunology Letters·A Rolink, F Melchers
Jul 9, 1999·Immunology Letters·A G RolinkF Melchers
Sep 2, 1998·Current Opinion in Immunology·M E Conley, M D Cooper
May 16, 1998·The Journal of Experimental Medicine·N SolvasonM Howard
Sep 9, 1998·The Journal of Experimental Medicine·A B SatterthwaiteO N Witte
Jul 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robin LesleyJason G Cyster
Mar 18, 2005·Annual Review of Immunology·Hassan JumaaMichael Reth
Aug 23, 2005·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Hiroko TanabeTakashi Shimada
Oct 3, 1999·European Journal of Immunology·M KnödelA Schimpl
Mar 15, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yang-Yang FengTakeshi Tsubata
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·D B SchubartP Matthias
Jan 30, 2020·Frontiers in Cellular and Infection Microbiology·Luan Firmino-CruzHerbert Leonel de Matos Guedes
Aug 31, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marc A SchwartzDavid J Rawlings
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eric H EklandJason G Cyster
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J J KennyD L Longo
Jun 17, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·D J Rawlings

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.