Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan.

Pain
Tetsuro NikaiAndrew H Ahn

Abstract

Sumatriptan and the other triptan drugs target the serotonin receptor subtypes1B, 1D, and 1F (5-HT(1B/D/F)), and are prescribed widely in the treatment of migraine. An anti-migraine action of triptans has been postulated at multiple targets, within the brain and at both the central and peripheral terminals of trigeminal "pain-sensory" fibers. However, as triptan receptors are also located on "pain-sensory" afferents throughout the body, it is surprising that triptans only reduce migraine pain in humans, and experimental cranial pain in animals. Here we tested the hypothesis that sumatriptan can indeed reduce non-cranial, somatic and visceral pain in behavioral models in mice. Because sumatriptan must cross the blood brain barrier to reach somatic afferent terminals in the spinal cord, we compared systemic to direct spinal (intrathecal) sumatriptan. Acute nociceptive thresholds were not altered by sumatriptan pre-treatment, regardless of route. However, in behavioral models of persistent inflammatory pain, we found a profound anti-hyperalgesic action of intrathecal, but not systemic, sumatriptan. By contrast, sumatriptan was completely ineffective in an experimental model of neuropathic pain. The pronounced activity of intrathec...Continue Reading

References

Oct 1, 1992·Pain·A TjølsenK Hole
Oct 1, 1990·Cephalalgia : an International Journal of Headache·M SkingleP P Humphrey
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
May 1, 1997·Cephalalgia : an International Journal of Headache·H E ConnorP P Humphrey
Jun 5, 1997·European Journal of Pharmacology·M J CumberbatchR J Hargreaves
Feb 9, 1999·Cephalalgia : an International Journal of Headache·M J CumberbatchR J Hargreaves
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·A I Basbaum
Feb 5, 2000·Neuroscience·G Wotherspoon, J V Priestley
Jun 18, 2002·British Journal of Anaesthesia·R Nadeson, C S Goodchild
Aug 26, 2003·Advanced Drug Delivery Reviews·Carolyn A Fairbanks
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Shannon D ShieldsAllan I Basbaum
Mar 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dan LevyRami Burstein
Aug 26, 2004·Pain·E A JenningsM J Christie
Oct 13, 2004·European Journal of Pharmacology·Chang Young JeongMyung Ha Yoon
Mar 8, 2005·Life Sciences·Josélia B DaherCarlos R Tonussi
Sep 30, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amol M PatwardhanKenneth M Hargreaves
Jan 13, 2006·Journal of Pharmacokinetics and Pharmacodynamics·Mats BergströmBengt Långström
Aug 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew H Ahn, Allan I Basbaum
Aug 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·Colleen R McNamaraChristopher M Fanger

❮ Previous
Next ❯

Citations

Jun 6, 2009·Cephalalgia : an International Journal of Headache·E A BatesA H Ahn
Jun 20, 2012·Cephalalgia : an International Journal of Headache·Andrea M HarriottMichael S Gold
Nov 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric A KaiserAndrew F Russo
Mar 29, 2014·Current Opinion in Supportive and Palliative Care·Greg Dussor
Nov 12, 2009·Expert Review of Neurotherapeutics·Vinod Kumar Gupta
Jan 3, 2016·International Journal of Biological Macromolecules·Priti GirotraGaurav Kumar
Jan 19, 2016·Neuroscience·Luiz F FerrariPaul G Green
Jan 1, 2014·The Journal of Allergy and Clinical Immunology·Ferda CevikbasMartin Steinhoff
Aug 25, 2015·International Journal of Biological Macromolecules·Girotra Priti HansrajPawan Kumar
Jun 6, 2009·The Journal of Headache and Pain·Alessandro PanconesiLeonello Guidi
Apr 2, 2011·Headache·Jason J IvanusicErnest A Jennings
Apr 14, 2016·European Journal of Pharmacology·Guadalupe C Vidal-CantúEnriqueta Muñoz-Islas
Nov 15, 2014·European Journal of Pain : EJP·K DöringH H Krämer
Aug 11, 2015·Frontiers in Pharmacology·Roberta CarbonaraJean-François Desaphy
Oct 15, 2013·Pain·Amynah A PradhanAndrew Charles
Oct 16, 2015·European Journal of Pharmacology·Danielle A DinizThiago R L Romero
May 1, 2020·British Journal of Pharmacology·Bryony L WintersChristopher W Vaughan
Apr 2, 2021·Drug Development Research·Moein AlaAhmad Reza Dehpour
Oct 25, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Alisson OshiroDaniele R de Araujo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Blood Brain Barrier & Cytokines

Some cytokines are able to cross the blood brain barrier through transport systems and enter the cerebrospinal fluid and interstitial fluid spaces. Here is the latest research on cytokines crossing the blood brain barrier and how this can affect tissues within the CNS.