Abstract
The ventricular zone (VZ) and subventricular zone (SVZ) of the fetal brain are generally believed to give rise to all the neurons and glia that will populate the cerebral hemispheres. In rodents a mitotically active cell (progenitor cell) has been identified outside the VZ and SVZ, in the intermediate zone (IZ) of the cerebral hemisphere. The cell types that arise from these progenitor cells remain uncertain. We have set out to determine if a similar population of mitotically active cells is present in the IZ during human brain development, and to try and define the cell type that arise from this progenitor cell. Using a monoclonal antibody that recognizes proliferating cell nuclear antigen (PCNA), a replication-specific protein, the cerebral hemispheres from 9 human fetal and infant brains between ages of 15 and 38 weeks gestation were studied. PCNA-immunopositive cells were found in the internal capsule and cerebral white matter with approximately equal frequency and rarely in the cerebral cortex between 15 and 20 weeks gestation. In the internal capsule, the number of positive cells decreased by the end of the second trimester; however, a relatively constant number of PCNA-positive cells remained in the cerebral white matter...Continue Reading
Citations
Jul 13, 1999·Microscopy Research and Technique·A SimonatiN Rizzuto
Jul 19, 2002·The Anatomical Record·Wood Yee ChanDavid T Yew
Mar 2, 2005·Acta Neuropathologica·Portia A KreigerJeffrey A Golden
May 7, 2005·Acta Neuropathologica·Chris EnglundRobert F Hevner
May 13, 2005·Histochemistry and Cell Biology·Gamze TanrioverUmit A Kayisli
Aug 25, 2007·Brain Structure & Function·Rosalind S E CarneyZoltán Molnár
Apr 12, 2011·Brain : a Journal of Neurology·Marc R Del Bigio
Jan 25, 2007·Neurosurgery Clinics of North America·Alfredo Quiñones-HinojosaJose Manuel Garcia-Verdugo
Apr 25, 2006·Epilepsy Research·A R JudkinsJ A Golden
Oct 21, 2005·Brain Research. Developmental Brain Research·Eva CandalIsabel Rodríguez-Moldes
Jul 16, 2002·Neurological Research·R NagaiN Urabe
Aug 13, 2015·BioMed Research International·Julia TichyMichel Mittelbronn
Feb 13, 2001·Molecular Cell·T LindstenC B Thompson
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P C Barradas, L A Cavalcante
Oct 11, 2005·Journal of Neuropathology and Experimental Neurology·Mark S FormanJeffrey A Golden
Jan 13, 2019·Stem Cell Research & Therapy·Chen KanLixin Kan
Sep 15, 2001·Journal of Neuropathology and Experimental Neurology·M R Santi, J A Golden