Progenitor cells of the rod-free area centralis originate in the anterior dorsal optic vesicle.

BMC Developmental Biology
Sae Kyung Shin, Keely M Bumsted O'Brien

Abstract

Nervous system development is dependent on early regional specification to create functionally distinct tissues within an initially undifferentiated zone. Within the retina, photoreceptors are topographically organized with rod free area centrales faithfully generated at the centre of gaze. How does the developing eye regulate this placement? Conventional wisdom indicates that the distal tip of the growing optic vesicle (OV) gives rise to the area centralis/fovea. Ectopic expression and ablation studies do not fully support this view, creating a controversy as to the origin of this region. In this study, the lineage of cells in the chicken OV was traced using DiI. The location of labelled cells was mapped onto the retina in relation to the rod-free zone at embryonic (E) 7 and E17.5. The ability to regenerate a rod free area after OV ablation was determined in conjunction with lineage tracing. Anterior OV gave rise to cells in nasal retina and posterior OV became temporal retina. The OV distal tip gave rise to cells above the optic nerve head. A dorsal and anterior region of the OV correlated with cells in the developing rod free area centralis. Only ablations including the dorsal anterior region gave rise to a retina lacking a ...Continue Reading

References

Dec 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V Hamburger, H L Hamilton
Oct 1, 1992·Neuroscience Research·T MatsunoH Nakamura
May 1, 1992·Optometry and Vision Science : Official Publication of the American Academy of Optometry·T D Williams, J M Wilkinson
Jun 20, 1991·Nature·G M RattoP A McNaughton
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·C L CepkoD Ezzeddine
Feb 3, 1997·The Journal of Comparative Neurology·K BumstedA Hendrickson
Nov 30, 2000·Survey of Ophthalmology·B C OnwocheiE Mir
Nov 1, 2001·Annual Review of Cell and Developmental Biology·R L Chow, R A Lang
Aug 29, 2003·Development·Michael E ZuberWilliam A Harris
Aug 24, 2004·The Journal of Biological Chemistry·Laurence LeconteSimon Saule
Dec 4, 2004·Development·D Jonathan HorsfordRoderick R McInnes
Dec 14, 2004·Journal of Medical Genetics·C Y Gregory-EvansK Gregory-Evans
Mar 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dorothea SchulteConstance L Cepko
Mar 6, 2007·Developmental Biology·Ruben Adler, M Valeria Canto-Soler
Sep 10, 2008·Experimental Eye Research·Anita HendricksonJan Provis
Oct 16, 2008·BMC Developmental Biology·Jeffrey M TrimarchiConstance L Cepko

❮ Previous
Next ❯

Citations

Apr 25, 2013·PloS One·Sara J VentersJeanette Hyer
Oct 21, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sara J VentersJeanette Hyer
Mar 1, 2012·Developmental Biology·Gonzalo UgarteGiulio Cossu

❮ Previous
Next ❯

Methods Mentioned

BETA
dissecting

Software Mentioned

PASCAL
Adobe Photoshop

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Actin, Myosin & Cell Movement

Contractile forces generated by the actin-myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Here is the latest research on the roles of actin and myosin in cell movement.