Progenitors from the postnatal forebrain subventricular zone differentiate into cerebellar-like interneurons and cerebellar-specific astrocytes upon transplantation.

Molecular and Cellular Neurosciences
Ana MilosevicJames E Goldman

Abstract

Forebrain subventricular zone (SVZ) progenitor cells give rise to glia and olfactory bulb interneurons during early postnatal life in rats. We investigated the potential of SVZ cells to alter their fate by transplanting them into a heterotypic neurogenic and gliogenic environment-the cerebellum. Transplanted cells were examined 1 to 7 weeks and 6 months post transplantation. Forebrain progenitors populated the cerebellum and differentiated into oligodendrocytes, cerebellar-specific Bergmann glia and velate astrocytes, and neurons. The transplanted cells that differentiated into neurons maintained an interneuronal fate: they were GABA-positive, expressed interneuronal markers, such as calretinin, and exhibited membrane properties that are characteristic of interneurons. However, the transplanted interneurons lost the expression of the olfactory bulb transcription factors Tbr2 and Dlx1, and acquired a cerebellar-like morphology. Forebrain SVZ progenitors thus have the potential to adapt to a new environment and integrate into diverse regions, and may be a useful tool in transplantation strategies.

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Citations

Oct 16, 2012·Development and Psychopathology·Hanna E StevensFlora M Vaccarino
Jul 21, 2009·Progress in Neurobiology·Mary C Whitman, Charles A Greer
Jan 6, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Flora M VaccarinoSherman Weissman
Apr 14, 2010·The European Journal of Neuroscience·Constantino Sotelo
Aug 15, 2014·Frontiers in Cellular Neuroscience·Giulio Srubek Tomassy, Valentina Fossati
Oct 23, 2016·The Journal of Comparative Neurology·Ana MilosevicPaul Greengard
Apr 4, 2017·Frontiers in Biology·Gabrielle Rushing, Rebecca A Ihrie

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