Progeny of old parents have increased social space in Drosophila melanogaster

Scientific Reports
Dova B Brenman-SuttnerAnne F Simon

Abstract

We report the effects of aging and parental age in Drosophila melanogaster on two types of responses to social cues: the choice of preferred social spacing in an undisturbed group and the response to the Drosophila stress odorant (dSO) emitted by stressed flies. The patterns of changes during aging were notably different for these two social responses. Flies were initially closer in space and then became further apart. However, the pattern of change in response to dSO followed a more typical decline in performance, similarly to changes in locomotion. Interestingly, the increased social space of old parents, as well as their reduced performance in avoiding dSO, was passed on to their progeny, such that young adults adopted the behavioural characteristic of their old parents. While the response to social cues was inherited, the changes in locomotion were not. We were able to scale the changes in the social space of parents and their progeny by accelerating or decelerating the physiological process of aging by increasing temperatures and exposure to oxidative stress, or via caloric restriction, respectively. Finally, when we aged only one parent, only the male progeny of old fathers and the progeny of very old mothers were more di...Continue Reading

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Citations

Feb 13, 2019·PloS One·Anna Castells-NobauAnnette Schenck
Jul 10, 2019·Genes, Brain, and Behavior·Dova B Brenman-SuttnerAnne F Simon
Jul 19, 2019·Frontiers in Genetics·Kevin A HopeLawrence T Reiter
May 16, 2019·Disease Models & Mechanisms·Mireia Coll-TanéAnnette Schenck
Jul 3, 2020·International Journal of Molecular Sciences·Ryley T YostAnne F Simon

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Methods Mentioned

BETA
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Software Mentioned

ImageJ
GraphPad Prism7
GraphPad Prism
GraphPad

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