Progesterone administration in vivo stimulates release of luteinizing hormone-releasing hormone in vitro

Science
V D RamirezD Lin

Abstract

The release of luteinizing hormone-releasing hormone (LHRH) from tissue from the mediobasal hypothalamic-anterior hypothalamic-preoptic area of prepuberal female rats was measured in a perfusion system. Measurements were also made of the concentrations of LHRH in these tissue fragments and of luteinizing hormone in serum obtained when the rats were killed. Four groups of immature rats were studied: intact, ovariectomized, ovariectomized and implanted with estradiol-containing capsules, and ovariectomized rats primed with estradiol and injected with progesterone. The release of LHRH from the tissue of ovariectomized animals was significantly less than that of intact females and was not modified when the ovariectomized rats received estradiol. However, there was a four- to fivefold increase in LHRH release from tissue of ovariectomized rats primed with estradiol when they were killed 6 hours after they received an injection of progesterone. The concentrations of LHRH in tissue and of luteinizing hormone in serum varied among groups and with the time of day that the animals were killed. The interactions among luteinizing hormone, gonadal steroids, and the photoperiod seem to set the appropriate conditions for neural processes trig...Continue Reading

References

May 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·E Gallardo, V D Ramirez
Jan 1, 1979·Neuroendocrinology·M E MolitchW D Odell
Dec 2, 1976·Nature·D K SarkarN M Sherwood
Jan 1, 1975·Endocrinology·S J Legan, F J Karsch
Apr 1, 1976·The American Journal of Physiology·M MolitchW D Odell
Aug 1, 1974·The Journal of Endocrinology·K Brown-Grant
May 1, 1973·The Journal of Clinical Endocrinology and Metabolism·T M NettW F White
Mar 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·J A ColomboC H Sawyer
Aug 1, 1971·Endocrinology·L CaligarisS Taleisnik
Oct 1, 1966·The Journal of Endocrinology·F Döcke, G Dörner
Jan 1, 1980·Journal of Endocrinological Investigation·V D RamirezD Hartter
Jun 1, 1965·Endocrinology·V D RAMIREZ, C H SAWYER

❮ Previous
Next ❯

Citations

Mar 1, 1987·Journal of Steroid Biochemistry·S J BerticsH J Karavolas
Oct 19, 2002·Progress in Neurobiology·Roberto C MelcangiMariarita Galbiati
Jul 1, 1994·Neurochemical Research·L CovarrubiasJ L Charli
Dec 14, 1999·Journal of Endocrinological Investigation·A E CalogeroR D'Agata
Jan 1, 1988·American Journal of Primatology·Donald C Meyer, Gerald J Pepe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.