PMID: 19912860Jun 1, 1992Paper

Progesterone and corticosteroid regulation of hypothalamic and pituitary opioid content during LH surge induction

Molecular and Cellular Neurosciences
D BrannV Mahesh

Abstract

The purpose of this study was to determine whether steroid hormones affect brain opioid content during the time of gonadotropin surge induction. Ovariectomized rats (26 days old) were primed with estradiol (E(2)) (2 mug) for 2 days. E(2) treatment markedly suppressed hypothalamic beta-endorphin content at 1500 h, 1800 h (Day 29), and 0800 h (Day 30) but had no effect on pituitary beta-endorphin levels. The administration of progesterone (P(4)) at 0900 h on Day 29 caused a luteinizing hormone (LH) and a follicle-stimulating hormone (FSH) surge at 1500 h that same day. Interestingly, hypothalamic beta-endorphin content was unchanged during the LH surge induced by P(4), although a nonsignificant elevation of hypothalamic beta-endorphin levels was noticed in P(4)-treated rats the morning after the surge. Triamcinolone acetonide (TA) treatment induced a large LH and FSH surge at 1500 h. Similar to P(4), TA did not alter hypothalamic beta-endorphin levels during the time of the LH surge; however, after the surge, TA-treated rats had a significant increase in hypothalamic beta-endorphin levels at 1800 h (Day 29) and 0800 h the next morning. Cortisol had no effect on LH levels but increased FSH levels at 0800 h on Day 30. Similar to TA...Continue Reading

References

Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·V B Mahesh, D W Brann
Mar 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·D W BrannV B Mahesh
Jan 1, 1988·Journal of Steroid Biochemistry·S P KalraW R Crowley
Mar 1, 1985·Neuroendocrinology·J C Peduto, V B Mahesh
Aug 1, 1984·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A Pfeiffer, A Herz
Jan 1, 1983·Endocrine Reviews·S P Kalra, P S Kalra
Aug 1, 1990·Molecular and Cellular Neurosciences·Y TongG Pelletier

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Citations

Jul 20, 2002·Microbial Pathogenesis·Bradley L Allen, Magnus Höök
Oct 27, 2011·American Journal of Physiology. Endocrinology and Metabolism·Virendra B Mahesh

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