Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast

Molecular and Cellular Endocrinology
H N HiltonC L Clarke

Abstract

Progesterone is critical in normal breast development and its synthetic derivatives are emerging as major drivers of breast cancer risk. The recent demonstration that progesterone regulates the stem cell compartment in the murine mammary gland, despite the absence of progesterone receptor (PR) in mammary stem cells, highlights the fact that PR distribution in progenitor cell subsets in the human breast remains to be conclusively shown. By utilising two independent cell sorting strategies to fractionate cells into distinct subpopulations enriched for different cell lineage characteristics, we have demonstrated a consistent enrichment of PR transcripts, relative to estrogen receptor transcripts, in the bipotent progenitor subfraction in the normal human breast. We have also shown co-expression of both steroid hormone receptors with basal markers in a subset of human breast cells, and finally we have demonstrated that PR+ bipotent progenitor cells are estrogen-insensitive, and that estrogen regulates PR in mature luminal cells only.

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Citations

Oct 12, 2012·Breast Cancer Research and Treatment·Julia Y S TsangGary M Tse
Jan 8, 2014·Breast Cancer Research and Treatment·Heidi N HiltonC L Clarke
Dec 3, 2013·Pharmacology & Therapeutics·Todd P Knutson, Carol A Lange
Jul 21, 2015·Journal of Mammary Gland Biology and Neoplasia·Lisa M Arendt, Charlotte Kuperwasser
Jul 22, 2015·Journal of Mammary Gland Biology and Neoplasia·Giusy Tornillo, Matthew J Smalley
Sep 24, 2015·Journal of Mammary Gland Biology and Neoplasia·Gerard A TarulliTheresa E Hickey
May 7, 2015·Endocrine-related Cancer·Pratima BasakAfshin Raouf
Jan 15, 2015·Journal of Molecular Endocrinology·Caroline H DiepCarol A Lange
Oct 29, 2014·PloS One·Lisa M ArendtCharlotte Kuperwasser
Jul 7, 2016·Journal of Molecular Biology·Sandra L GrimmDean P Edwards
Aug 9, 2015·Journal of Mammary Gland Biology and Neoplasia·Heidi N Hilton, Christine L Clarke
Aug 14, 2018·Journal of Mammary Gland Biology and Neoplasia·Gerard A TarulliTheresa E Hickey
Sep 2, 2020·Cancers·Diego A PedrozaRajkumar Lakshmanaswamy

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