PMID: 8587697Jul 1, 1995Paper

Progesterone and glucocorticoid receptor activation in meningiomas

Neurosurgery
R S CarrollP M Black

Abstract

The possibility that the female sex steroid progesterone plays a role in meningioma proliferation has been suggested by a number of investigators, and it has been shown that many meningiomas have high-affinity progesterone binding sites. There has been a long-standing debate in the literature as to whether the progesterone receptors that are present in meningiomas are functional. We recently showed, by the use of immunohistochemistry, that the progesterone receptor in meningiomas is localized to the nucleus, suggesting that the receptor is in a location to be activated. In this study, eight meningioma cell cultures were transiently transfected with a construct that contains two palindromic progesterone/glucocorticoid response elements in front of the thymidine kinase promoter and the chloramphenicol acetyl sequence of the tyrosine aminotransferase gene. In all meningioma cell cultures, an increase in the transcription of the progesterone response element construct was observed in the presence of dexamethasone, suggesting that the glucocorticoid receptor in meningiomas is functional. An increase in transcription was observed with the addition of promegestone (R5020), a progesterone agonist, only in meningioma cell cultures that ...Continue Reading

References

Feb 1, 1979·Cancer·S H AdvaniP B Desai
Apr 1, 1979·Journal of Neurosurgery·M S DonnellW L Donegan
Jul 1, 1992·Clinical Endocrinology·S W LambertsE P Krenning
Jan 1, 1992·Acta neurochirurgica·M Perrot-ApplanatM Kujas
Jun 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·S W LambertsH de Jong
Jan 1, 1991·Radiation and Environmental Biophysics·A M KuzinE G Mozgovoi
Jun 1, 1991·Journal of Neurosurgery·S M GrunbergL L Stevenson
Mar 1, 1989·Neurological Research·F MaiuriF D'Andrea
Feb 10, 1989·Cell·M Beato
Mar 1, 1989·Surgical Neurology·E R Waelti, T M Markwalder
Jun 1, 1987·Journal of Neurology·K P LeschP Thierauf
Feb 1, 1987·Archives of Neurology·N C RoelvinkB R Rao
Apr 1, 1987·Journal of Neurosurgery·J J OlsonP M Loh
Jul 1, 1986·Journal of Neurosurgery·J J OlsonP M Loh
Jan 1, 1985·Annual Review of Genetics·K R Yamamoto
Jan 1, 1986·Acta neurochirurgica·G BlaauwS W Lamberts
May 1, 1985·Journal of Neurosurgery·R L MartuzaD T MacLaughlin
May 1, 1985·Journal of Neurosurgery·J R JayR L Martuza
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Jan 1, 1984·Clinical Neuropharmacology·M Poisson
Jan 1, 1984·Clinical Neuropharmacology·E HaywardD M Barnes
Jan 1, 1984·Clinical Neuropharmacology·T M MarkwalderD T Zava
Mar 1, 1983·European Journal of Cancer & Clinical Oncology·M A BlankensteinE Mulder
May 1, 1984·Journal of Neurosurgery·D W CahillT B Ducker
Feb 15, 1982·Cancer·L L TilzerK Alward
Feb 3, 1990·Healthcare Management Forum·J M Horne

❮ Previous
Next ❯

Citations

May 14, 2004·The Neurologist·Katharine J DrummondPeter McL Black
Apr 7, 2007·Neurosurgery·Theresa G CargioliRona S Carroll
Oct 27, 2011·The Oncologist·Santosh SarafJ Lee Villano
Jan 16, 2007·Journal of Neurosurgery·Svetlana PravdenkovaMuhammad Husain
Jul 19, 2014·Clinical Neurology and Neurosurgery·A Celal IplikciogluDeniz Ozcan
Apr 14, 2005·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Justin S SmithMichael W McDermott
Dec 12, 2002·Chest·Tarja Saaresranta, Olli Polo
Aug 21, 2007·Surgical Neurology·Mustafa Aziz HatibogluDeniz Ozcan
Jan 24, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Xu ZhaoSheng Cheng Wei
Jun 12, 2001·Journal of Neuropathology and Experimental Neurology·D X CaiA Perry
Jul 29, 1997·International Journal of Cancer. Journal International Du Cancer·M LambeJ Baron
Nov 6, 2002·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Asha DasDuncan R Smith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.