Progesterone and preterm birth.

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Jane E Norman

Abstract

Progestogens (vaginal progesterone and intramuscular 17-hydroxyprogesterone acetate) are widely recommended for women at high risk of preterm birth. Typical regimens include 17-hydroxyprogesterone caproate (250 mg intramuscularly weekly), starting at 16-20 gestational weeks until 36 weeks or delivery for women with a singleton gestation and a history of spontaneous preterm birth, or vaginal progesterone (90-mg vaginal gel or 200-mg micronized vaginal soft capsules) for women with a short cervix (typically ≤25 mm). Although some randomized trials support this approach, neither of the largest trials (PROLONG for 17-hydroxyprogesterone acetate or OPPTIMUM for vaginal progesterone) demonstrated efficacy. There are almost no data on long-term effects, and none that shows benefit beyond the neonatal period. Although some analyses suggest the cost-effectiveness of the approach, a cervical length screening program followed by progesterone for those with a short cervix will reduce preterm birth rates by less than 0.5%. The present review assesses evidence on the efficacy, likely impact, and long-term effects of implementing the recommendations for progestogens in full. Clinicians and pregnant women can look forward to resolution of the ...Continue Reading

References

May 18, 2000·The New England Journal of Medicine·R L GoldenbergW W Andrews
Sep 17, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L Valentin, I Bergelin
Jun 13, 2003·The New England Journal of Medicine·Paul J MeisUNKNOWN National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
May 18, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·H-J ChenJ-L Hwang
Oct 2, 2007·Obstetrics and Gynecology·Allison T NorthenUNKNOWN National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network
Apr 8, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S S HassanUNKNOWN PREGNANT Trial
Aug 2, 2013·The Cochrane Database of Systematic Reviews·Jodie M DoddCaroline A Crowther
Dec 8, 2014·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics· Figo Working Group On Best Practice In Maternal-Fetal Medicine
Feb 18, 2015·Nature Reviews. Neurology·Henrik HagbergPierre Gressens
Jun 15, 2015·American Journal of Obstetrics and Gynecology·Erika F WernerStephen F Thung
Jan 29, 2016·American Journal of Obstetrics and Gynecology·Siddharth JainJohn Owen
Feb 18, 2016·American Journal of Obstetrics and Gynecology·Brett D EinersonEmily S Miller
Jul 2, 2016·Human Reproduction Update·Ramkumar MenonRobert N Taylor
Jul 22, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·Matthew Prior, Jim G Thornton
Jul 22, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·Kacey Y Eichelberger, Tracy A Manuck
Jul 23, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R RomeroS S Hassan
Jan 28, 2017·American Journal of Obstetrics and Gynecology·UNKNOWN Society for Maternal-Fetal Medicine (SMFM) Publications Committee
Mar 21, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·M PriorJ G Thornton

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Citations

Jun 12, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Bo Jacobsson, Joe Leigh Simpson
Mar 4, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yuka SatoKiyoko Kato
Dec 3, 2021·Obstetrics and Gynecology·Rodolfo C PacagnellaUNKNOWN P5 Working Group

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