Progesterone antagonizes the positive influence of estrogen on Chlamydia trachomatis serovar E in an Ishikawa/SHT-290 co-culture model

Pathogens and Disease
Jennifer KintnerJennifer Vanover Hall

Abstract

Studies indicate that estrogen enhances Chlamydia trachomatis serovar E infection in genital epithelial cells. Hormones have direct and indirect effects on endometrial epithelial cells. Estrogen and progesterone exposure induces endometrial stromal cells to release effectors that subsequently regulate growth and maturation of uterine epithelial cells. Estrogen enhances C. trachomatis infection by aiding entry and intracellular development in endometrial epithelial cell (Ishikawa, IK)/SHT-290 stromal cell co-culture. Enhanced chlamydial infection was mediated by direct estrogen-stimulated signaling events in epithelial cells and indirectly via estrogen-induced stromal cell effectors. The current study investigates the effects of hormones on chlamydial development using culture conditions representative of the menstrual cycle. Chlamydia trachomatis-infected IK or IK/SHT-290 cultures were exposed to 10(-8) M estrogen (E2), 10(-7) M progesterone (P4) or a combination of both hormones (10(-8) M E2 followed by 10(-9) M E2/10(-7) M P4). Chlamydial infectivity and progeny production were significantly decreased (30-66%) in cultures exposed to progesterone or estrogen/progesterone combination compared to estrogen alone. Thus, progestero...Continue Reading

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Citations

Apr 26, 2016·Nature Reviews. Microbiology·Cherilyn ElwellJoanne Engel
Jan 13, 2018·Frontiers in Cellular and Infection Microbiology·Jennifer KintnerJennifer V Hall
Jan 1, 2020·Current Clinical Microbiology Reports·Amy Berry, Jennifer V Hall
Mar 14, 2021·Enfermedades infecciosas y microbiología clínica·Marcela López-HurtadoFernando M Guerra-Infante

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