PMID: 3320533Jan 1, 1987Paper

Progesterone-associated proteins PP12 and PP14 in the human endometrium

Journal of Steroid Biochemistry
E M RutanenM L Huhtala

Abstract

Two proteins, designated as PP12 and PP14 were originally isolated from soluble extracts of the human placenta and its adjacent membranes. We have shown that they are synthesized by decidualized/secretory endometrium and not by placenta. Both proteins occur at high concentrations in human amniotic fluid, which is therefore an excellent source for purification. PP12 is a 34-kDa glycoprotein, which has an N-terminal amino acid sequence of Ala-Pro-Trp-Gln-Cys-Ala-Pro-Cys-Ser-Ala. This is identical with that of somatomedin-binding protein purified from the amniotic fluid. PP12 too binds somatomedin-C, or IGF-I (insulin-like growth factor-I). Human secretory endometrium synthesizes and secretes PP12, and progesterone stimulates its secretion. PP14 is a 28-kDa glycoprotein. Its N-terminal sequence shows homology to that of beta-lactoglobulins from various species. We have found PP14 in the human endometrium, serum and milk. Immunologically, PP14 is related to progestagen-associated endometrial protein (PEP), alpha-2 pregnancy-associated endometrial protein (alpha-2, PEG), endometrial protein 15 (EP15), alpha-uterine protein (AUP) and chorionic alpha-2 microglobulin (CAG-2). In ovulatory menstrual cycles, the concentration of PP14 inc...Continue Reading

References

Mar 1, 1986·Endocrinology·E M RutanenM Seppälä
May 1, 1986·Endocrinology·M JulkunenM Seppälä
Jun 1, 1986·Acta Endocrinologica·M Julkunen
Sep 1, 1986·The Journal of Clinical Endocrinology and Metabolism·E M RutanenJ G Grudzinskas
Jan 1, 1985·Annals of the New York Academy of Sciences·M SeppäläT Wahlström
Apr 1, 1985·Endocrinology·E M RutanenM Seppälä
Nov 1, 1985·British Journal of Obstetrics and Gynaecology·R J HowellT Chard
Nov 1, 1985·British Journal of Obstetrics and Gynaecology·M JulkunenM Seppälä
Oct 1, 1984·British Journal of Obstetrics and Gynaecology·E M RutanenM Seppälä
Jul 1, 1980·Journal of Reproduction and Fertility·S G JoshiD P Swartz
May 1, 1982·Journal of Reproduction and Fertility·R G SutcliffeJ F Bank

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Citations

Mar 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A A BrooksH I Abdalla
May 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·S TabanelliE Gurpide
Dec 1, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D FothT Römer
Jun 5, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dolores Foth, Thomas Römer
Dec 1, 1991·Baillière's Clinical Endocrinology and Metabolism·D R Brigstock
Dec 1, 1991·American Journal of Reproductive Immunology : AJRI·N OkamotoT Mori
Jan 1, 1991·Annals of the New York Academy of Sciences·T MoriY Umaoka
Oct 22, 2003·Reproductive Biomedicine Online·Rekha M RaoA Jagannadha Rao
Feb 1, 1990·Differentiation; Research in Biological Diversity·F SchatzE Gurpide
Apr 14, 2000·American Journal of Obstetrics and Gynecology·R N TaylorM D Mueller
Sep 3, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·K NirgianakisM D Mueller
Oct 12, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·B A Lessey
Oct 19, 2001·Gynecologic Oncology·D Günter Kieback, D C Fischer
Jan 31, 2020·Biomechanics and Modeling in Mechanobiology·Tatyana KupermanDan Grisaru
Apr 23, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marc A SchneiderMichael Meister

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