Progesterone does not influence vascular function in postmenopausal women

Journal of Hypertension
Suzy Y HonisettPaul A Komesaroff

Abstract

The protective functions of oestrogen therapy alone on cardiovascular risk parameters are well established; however, the action of progesterone on vascular parameters in an oestrogen-deprived environment is less clear. To examine the effects of progesterone alone on vascular function and hormone levels in postmenopausal women. In a randomized, double-blind, cross-over design study, 20 healthy postmenopausal women were tested before and after 6 weeks of treatment with micronized progesterone (100 mg/daily) and matching placebo. Tests included measurement of sex hormones and gonadatropin levels, lipids and measures of surrogate markers of vascular function including, blood pressure, flow-mediated dilation of the brachial artery, systemic arterial compliance and cutaneous vascular reactivity. The mean (+/- SEM) age of subjects was 56.4 +/- 2.7 years and the average body mass index at the baseline visit was 27.1 +/- 1.0 kg/m2. Progesterone levels increased as a result of progesterone treatment (0.9 +/- 0.2 to 9.5 +/- 2.3 nmol/l, P = 0.001), whereas follicle-stimulating hormone levels decreased (75.1 +/- 11.4 to 67.6 +/- 10.0, P = 0.001). Systemic arterial compliance, flow mediated dilation, cutaneous vascular reactivity, blood pres...Continue Reading

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Citations

Aug 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jennifer A MinerChristopher T Minson
Oct 1, 2014·Menopause : the Journal of the North American Menopause Society·Zeinab IssaGhada El-Hajj Fuleihan
Sep 23, 2020·Women & Health·Marcio Alexandre Hipolito Rodrigues, Anne Gompel
Dec 5, 2003·Journal of Hypertension·Nikolaus J Buchner, Lars C Rump
Mar 28, 2012·Climacteric : the Journal of the International Menopause Society·A O Mueck
Nov 22, 2017·Lipids in Health and Disease·Yifan Jiang, Weijie Tian
Sep 15, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzette M Evans, Richard W Foltin
Jan 18, 2018·Post Reproductive Health·Louise Newson
Sep 10, 2011·Drugs·Pierre BoutouyrieAzra Mahmud

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