Progesterone does not inhibit gonadotropin-induced follicular maturation in the female rhesus monkey (Macaca mulatta)

Endocrinology
A J Zeleznik, J A Resko

Abstract

Female rhesus monkeys were treated with exogenous human menopausal gonadotropin (Pergonal) in the presence of exogenous systemic progesterone provided by Silastic implants and during the luteal phase of the menstrual cycle to determine if progesterone influences gonadotropin-induced follicular maturation. Peripheral serum and ovarian vein plasma 17 beta-estradiol concentrations were used to assess the response to gonadotropin treatment. When systemic levels of progesterone were elevated to 6--10 ng/ml in eight animals during the midfollicular phase of the menstrual cycle, each animal responded to exogenous gonadotropin with a sustained increase in serum 17 beta-estradiol concentration, which reached levels of approximately 800 pg/ml during treatment. To determine if the corpus luteum itself influences the ovarian response to exogenous gonadotropin, animals were treated with exogenous gonadotropin for 7 days, commencing during either the follicular phase of the cycle or the midluteal phase of the cycle. Regardless of the time of initiation of gonadotropin treatment, peripheral serum 17 beta-estradiol levels rose to approximately 1 ng/ml in all animals studied. 17 beta-Estradiol levels were elevated in ovarian venous blood from t...Continue Reading

Citations

Apr 11, 2008·Endocrine·Rosalba Escamilla-HernandezA J Zeleznik
Feb 1, 1981·Molecular and Cellular Endocrinology·J R SchreiberG F Erickson
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·A J Zeleznik
Jan 1, 1987·Reproductive Toxicology·M C Rao, G Gibori
Aug 22, 2001·Biology of Reproduction·A J Zeleznik
Feb 1, 1997·Endocrine Reviews·B C Fauser, A M Van Heusden
Feb 1, 1996·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·F Scheele, J Schoemaker
May 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·B D BavisterR D Schultz
Apr 1, 1993·The American Journal of Physiology·G D GiraudK L Thornburg
Nov 1, 1982·The American Journal of Physiology·A L Goodman, G Hodgen
May 1, 1981·The American Journal of Physiology·J A ReskoE Knobil

Related Concepts

Androstenedione
Anthropoidea
Estradiol, (16 alpha,17 beta)-Isomer
Menstrual Cycle, Proliferative Phase
Luteal Phase
Macaca mulatta
HMG Lepori
Menstruation
Progesterone, (9 beta,10 alpha)-Isomer
Sterotate

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