Progesterone enhances learning and memory of aged wildtype and progestin receptor knockout mice.

Neuroscience Letters
C A Frye, Alicia A Walf

Abstract

Progesterone can enhance cognitive performance among young and aged mice; however, the mechanisms underlying these effects of progesterone are not well-understood. Aged, mice which lack functional progestin receptors (PRKO), or wildtype mice were administered progesterone (10mg/kg, SC), or vehicle, and learning/memory was evaluated. Progesterone, compared to vehicle, produced a conditioned place preference in PRKO and wildtype mice. Progesterone improved performance of PRKO and wildtype mice in the object placement, water maze, contextual and cued fear conditioning tasks. PRKO, compared to wildtype, mice performed better in the inhibitory avoidance task, irrespective of progesterone. Thus, progesterone to aged mice enhances performance across a variety of tasks and this may not require actions at PRs.

References

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Nov 16, 2004·Mechanisms of Ageing and Development·Xiaotao LiBert W O'Malley
Mar 15, 2006·Neurobiology of Learning and Memory·Alicia A WalfCheryl A Frye
Apr 20, 2006·Neurobiology of Aging·Lauren L HarburgerKaryn M Frick
May 18, 2007·Neurobiology of Learning and Memory·Cheryl A FryeAlicia A Walf
Sep 14, 2007·Neurochemistry International·Jonathan J HirstDavid W Walker
Nov 9, 2007·Neurobiology of Learning and Memory·Cheryl A Frye, Alicia A Walf
Apr 9, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Jason J Paris, Cheryl A Frye
Apr 29, 2008·Neuroscience Letters·Cheryl A Frye, Alicia A Walf

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Citations

Aug 7, 2012·Journal of Molecular Neuroscience : MN·Shiva Nasiraei-MoghadamLeila Dargahi
Jun 29, 2012·Biology of Mood & Anxiety Disorders·Kelimer Lebron-Milad, Mohammed R Milad
Aug 4, 2015·Behavioural Brain Research·Alicia A WalfCheryl A Frye
Dec 2, 2014·Neuroscience and Biobehavioral Reviews·L A BarrosM L Andersen
Jan 10, 2013·Neurobiology of Learning and Memory·Cristina S FonsecaGrace S Pereira
Aug 19, 2014·Behavioural Brain Research·Jennifer J TuscherKaryn M Frick

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