Progesterone enhances the surge of luteinizing hormone by increasing the activation of luteinizing hormone-releasing hormone neurons

Endocrinology
W S LeeG E Hoffman

Abstract

The ability of progesterone (P) to enhance the surge of LH in the rat is well documented, but whether its primary site of action is on the pituitary or brain is unclear. To determine whether P can alter the activation of LHRH neurons, 1) intact female rats were treated with the P antagonist RU486 (5 mg) at 1230 h on proestrus and killed at specified times during the afternoon and evening for comparison of plasma LH levels and cFos expression in LHRH neurons with untreated proestrous rats. RU486 treatment greatly reduced both the magnitude of the LH surge and the degree of cFos induction (numbers of cells expressing cFos and intensity of cFos staining) in LHRH neurons during proestrus. 2) Ovariectomized (OVX) rats were primed with estradiol benzoate (EB, 1 microgram) and then were treated with EB alone (50 microgram) or EB plus P (5 mg). Treatment with EB without P resulted in significantly lower peak LH levels and a reduced cFos response in LHRH neurons than the EB-P treated rats. These data suggest that the actions of P eventuate in an enhanced activation of LHRH neurons that may be responsible for the increased magnitude of the LH surge.

Citations

Jun 1, 1996·Cellular and Molecular Neurobiology·R Alonso-SolísA Hernández
Feb 1, 1995·Physiology & Behavior·D M WittD Crews
Mar 1, 1996·Molecular and Cellular Endocrinology·J K KepaM E Wierman
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·V B Mahesh, D W Brann
Jul 20, 2002·Frontiers in Neuroendocrinology·M Susan Smith, Kevin L Grove
Apr 20, 2002·Journal of Neuroendocrinology·G E Hoffman, D Lyo
Aug 31, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·A M BrownP Callahan
Oct 31, 2008·The FEBS Journal·Vien H Y LeeBilly K C Chow
Nov 1, 1993·Contraception·I M Spitz, C W Bardin
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·G N Wade, J E Schneider
Apr 15, 2015·Frontiers in Neuroscience·Atsushi FukushimaToshiya Funabashi
Oct 13, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Aleisha M Moore, Rebecca E Campbell
Nov 12, 2018·Journal of Neuroendocrinology·Aleisha M MooreRebecca E Campbell
May 5, 2006·Human Reproduction Update·Ioannis E Messinis
Nov 18, 2006·Endocrinology·E VigoM Tena-Sempere
Dec 22, 1999·The American Journal of Physiology·P M Wise

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