PMID: 11604259Oct 18, 2001Paper

Progesterone freeze-dried systems in sublingual dosage form

International Journal of Pharmaceutics
C VaugeladeC Bunel

Abstract

Various polymer matrices were tested to enhance progesterone bioavailability as part of an emergency therapy. Among the different polymers used, i.e. poly(N-vinylpyrrolidone) (PVP), poly(ethylene oxide) (PEO), Dextran T70 and partially saponified poly(methyl glyoxylate) (PMGz), the latter gives the fastest solubilization rate. The best results were obtained with the lyophilized dosage form instead of a simple mixture of the drug within the polymer matrix. A nearly instantaneous solubilization was observed with PMGz copolymers bearing 10-40% of carboxylic groups and containing up to 20% of the drug. The instantaneous solubilization of the PMGz matrix is due to the hydrophilic moieties, and the presence of hydrophobic zones in PMGz promotes good affinity with the drug and optimal dispersion into the matrix.

References

Jan 1, 1992·Journal of Pharmaceutical Sciences·D Harris, J R Robinson
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·S S HongC K Shim

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Citations

May 22, 2007·Journal of Pharmaceutical Sciences·Giorgio ZoppettiAdamo Fini
Aug 31, 2010·International Journal of Pharmaceutics·Jin-Ki KimSeongbong Jo
Aug 20, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Vittorio UnferGian Carlo Di Renzo
May 15, 2020·Journal of Oleo Science·Hiroki IdeguchiHiromichi Nakahara

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