PMID: 6538109Feb 27, 1984Paper

Progesterone in the ventromedial hypothalamus of ovariectomized, estrogen-primed rats inhibits subsequent facilitation of estrous behavior by systemic progesterone

Brain Research
B S Rubin, R J Barfield

Abstract

The putative neural target sites of progesterone's (P) inhibitory influence on estrous behavior were re-examined utilizing intracranial hormone implants. Subjects were estrogen-primed ovariectomized, Long-Evans rats, and all were outfitted with permanent indwelling guide cannulae aimed for the ventromedial hypothalamus (VMH), preoptic area (POA), or midbrain. In a series of 4 weekly testing paradigms, the ability of blank or P-filled implants to both facilitate estrous responsiveness and to interfere with an animal's ability to exhibit estrous behavior following a systemic injection of P 24 hours later was assessed. P-filled implants placed bilaterally into the VMH inhibited the subsequent facilitation of estrous behavior by systemic P administration. Neither P-filled implants in other brain regions nor blank implants lowered into the VMH had this same effect. Seven of the females that exhibited progesterone-induced behavioral refractoriness 24 h after P stimulation of the VMH exhibited facilitation of estrous responsiveness in behavioral tests given 4.5 h after cannulae placement suggesting that progesterone may exert its facilitative and inhibitory actions on estrous responsiveness at the same neuroanatomical locus.

References

Jan 1, 1979·Annual Review of Neuroscience·B S McEwenD W Pfaff
Apr 1, 1966·General and Comparative Endocrinology·R W GoyW C Young

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Citations

Mar 1, 1987·Journal of Steroid Biochemistry·S J BerticsH J Karavolas
Jan 1, 1985·Neurochemistry International·M Warembourg
Jan 1, 1984·Psychoneuroendocrinology·R J BarfieldA M Etgen
Dec 13, 2000·Brain Research Bulletin·M Satou, K Yamanouchi
Mar 24, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Cheryl A FryeMadeline E Rhodes
May 8, 2013·Hormones and Behavior·Sherri Lee JonesJames G Pfaus

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